Results 201 to 210 of about 120,389 (309)

The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage. [PDF]

Proc Natl Acad Sci U S A, 2021
De S, Holvey-Bates EG, Mahen K, Willard B, Stark GR.   +4 more
europepmc   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer

Drug Design, Development and Therapy
Chunyan Weng,1,* Rijuan Jin,1,* Xiaoliang Jin,1,* Zimei Yang,1,* Chenghai He,1,2 Qiuhua Zhang,1 Jingli Xu,1,3 Bin Lv1 1Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang ...
Weng C, Jin R, Jin X, Yang Z, He C, Zhang Q, Xu J, Lv B   +7 more
doaj  

Optimized isolation of enzymatically active ubiquitin E3 ligase E6AP/UBE3A from mammalian cells. [PDF]

Protein Expr Purif
Schafer JM, Muli CS, Heikal RA, Dyba MA, Tarasov SG, Stratton MM, Strieter ER, Walters KJ.   +7 more
europepmc   +1 more source

Influenza virus reduces ubiquitin E3 ligase MARCH10 expression to decrease ciliary beat frequency.

Am J Physiol Lung Cell Mol Physiol, 2023
Tsai M, Rayner RE, Chafin L, Farkas D, Adair J, Mishan C, Mallampalli RK, Kim SH, Cormet-Boyaka E, Londino JD.   +9 more
europepmc   +1 more source

Functional analysis of tomato CHIP ubiquitin E3 ligase in heat tolerance. [PDF]

Sci Rep, 2021
Zhang Y, Lai X, Yang S, Ren H, Yuan J, Jin H, Shi C, Lai Z, Xia G.   +8 more
europepmc   +1 more source

Structural Diversity of Ubiquitin E3 Ligase

The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Shimizu, Toshiyuki, Toma-Fukai, Sachiko
core  

The ubiquitin E3 ligase TRIM21 suppresses type I interferon signaling via STING degradation and ameliorates systemic autoimmunity. [PDF]

Exp Mol Med
Kim DS, Park Y, Tsokos GC, Cho ML, Kwok SK.   +4 more
europepmc   +1 more source

Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L. [PDF]

EMBO Rep
Zhu K, Chatrin C, Suskiewicz MJ, Aucagne V, Foster B, Kessler BM, Gibbs-Seymour I, Ahel D, Ahel I.   +8 more
europepmc   +1 more source

Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse. [PDF]

J Mol Cell Biol, 2021
Ma P, Li Y, Wang H, Mao B.
europepmc   +1 more source