Results 211 to 220 of about 231,680 (303)

The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination

The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by ...
N Gamage (9895226), YJ Choi (16371132), JU Jung (22380238), A Subasinghe (22089764), DK Haluwana (22057841), K Chathuranga (22089770), Y Seong (22380235), WA Gayan Chathuranga (22051877), P Rathnapala (22380232), A Weerawardhana (22380223), TH Kim (14462652), JS Lee (12018053)   +11 more
core  

Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium

Advanced Science, EarlyView.
Pediatric acute respiratory distress syndrome (PARDS) suppresses the FOXF1 transcription factor and disrupts lung development. This study shows that the FOXF1‐activating small‐molecule compound, TanFe[F], can be precisely delivered to lung endothelial cells using the innovative LEDD nanoparticle system.
Afzaal N. Mohammed, Zicheng Deng, Arnab Misra, Marcus Orzabal, Ananya Kondapally, Enhong Li, Jonathan Do, Ying‐Wei Lan, Fatemeh Kohram, Hunter Blackburn, Andreas Damianos, Tanya V. Kalin, Vladimir V. Kalinichenko   +12 more
wiley   +1 more source

Optimized isolation of enzymatically active ubiquitin E3 ligase E6AP/UBE3A from mammalian cells. [PDF]

Protein Expr Purif
Schafer JM, Muli CS, Heikal RA, Dyba MA, Tarasov SG, Stratton MM, Strieter ER, Walters KJ.   +7 more
europepmc   +1 more source

Influenza virus reduces ubiquitin E3 ligase MARCH10 expression to decrease ciliary beat frequency.

Am J Physiol Lung Cell Mol Physiol, 2023
Tsai M, Rayner RE, Chafin L, Farkas D, Adair J, Mishan C, Mallampalli RK, Kim SH, Cormet-Boyaka E, Londino JD.   +9 more
europepmc   +1 more source

The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage. [PDF]

Proc Natl Acad Sci U S A, 2021
De S, Holvey-Bates EG, Mahen K, Willard B, Stark GR.   +4 more
europepmc   +1 more source

E3 ubiquitin ligases and asthma relief

American Journal of Respiratory Cell and Molecular Biology
openaire   +3 more sources

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

The ubiquitin E3 ligase TRIM21 suppresses type I interferon signaling via STING degradation and ameliorates systemic autoimmunity. [PDF]

Exp Mol Med
Kim DS, Park Y, Tsokos GC, Cho ML, Kwok SK.   +4 more
europepmc   +1 more source

Functional analysis of tomato CHIP ubiquitin E3 ligase in heat tolerance. [PDF]

Sci Rep, 2021
Zhang Y, Lai X, Yang S, Ren H, Yuan J, Jin H, Shi C, Lai Z, Xia G.   +8 more
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source