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Role of E3 ubiquitin ligases in insulin resistance
Diabetes, Obesity and Metabolism, 2016E3 ubiquitin ligases are a large family of proteins that catalyse the ubiquitination of many proteins for degradation by the 26S proteasome. E3 ubiquitin ligases play pivotal roles in the process of insulin resistance and diabetes.
X-D, Yang, D-X, Xiang, Y-Y, Yang
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Trim45: An emerging E3 ubiquitin ligases in cancer
Cellular SignallingThe ubiquitin proteasome system is the major pathway for intracellular protein degradation and relies on ATP supply to specifically degrade misfolded or damaged proteins. The system consists of E1, E2, and E3 enzymes that mediate the ubiquitination modification of substrate proteins, followed by proteasomal recognition and degradation of the substrate ...
Huhu, Zhang +9 more
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C-Degron Mimicry Confers E3 Ligase Selectivity
Nature Reviews Molecular Cell Biology, 2023Lisa Heinke
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Ubiquitin Ligases: Guardians of Mammalian Development
Nature Reviews Molecular Cell Biology, 2022Alex N Bullock +2 more
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Structural Insights Into the Catalysis and Regulation of E3 Ubiquitin Ligases
Nature Reviews Molecular Cell Biology, 2016Danny T Huang, Lori Buetow
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SCF Ubiquitin Ligase-Targeted Therapies
Nature Reviews Drug Discovery, 2014Julia K Pagan +2 more
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Structure of a RING E3 Ligase and Ubiquitin-Loaded E2 Primed for Catalysis
Nature, 2012James Henderson Naismith +2 more
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