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Trim45: An emerging E3 ubiquitin ligases in cancer
Cellular SignallingThe ubiquitin proteasome system is the major pathway for intracellular protein degradation and relies on ATP supply to specifically degrade misfolded or damaged proteins. The system consists of E1, E2, and E3 enzymes that mediate the ubiquitination modification of substrate proteins, followed by proteasomal recognition and degradation of the substrate ...
Huhu, Zhang +9 more
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Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cell, 2023Kheewoong Baek +2 more
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Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy
Journal of Cell Biology, 2022Jun Zheng, Guisheng Zhong, Min Zhuang
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Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis
Annual Review of Biochemistry, 2021J Wade Harper, Brenda A Schulman
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SCF ubiquitin ligase-targeted therapies
Nature Reviews Drug Discovery, 2014Jeffrey R Skaar +2 more
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