Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental Disorders
BiomedicinesUbiquitination is a dynamic and tightly regulated post-translational modification essential for modulating protein stability, trafficking, and function to preserve cellular homeostasis.
Honoka Ashitomi +3 more
doaj +1 more source
Quantitative expression analysis of the cellular specificity of HECT-domain ubiquitin E3 ligases [PDF]
, 2000 Liliana E. Scarafia +2 more
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Post‐Translational Modifications of TOE3 Regulate Antiviral Defense in Tobacco
Advanced Science, EarlyView.CK2αL phosphorylates TOE3 and enhances its stability, while FBXL1 promotes the ubiquitination‐degradation of TOE3 via the 26S proteasome. Compared to CK2αL‐phosphorylated TOE3, nonphosphorylated TOE3 shows a much higher affinity for FBXL1 and is more susceptible to ubiquitination‐degradation, thus facilitating viral infection. The regulatory mechanisms
Bolei Jiao +3 more
wiley +1 more source
NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets
Journal of Orthopaedic Surgery and ResearchOsteoporosis is a systemic skeletal disorder characterized by reduced bone density and an increased risk of fractures, particularly prevalent in the aging population.
Heng Wu +4 more
doaj +1 more source
Advanced Science, EarlyView.Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu +25 more
wiley +1 more source
Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4 [PDF]
, 2000 Corina N. Jolliffe +4 more
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NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA
Advanced Science, EarlyView.MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen +13 more
wiley +1 more source
Advanced Science, EarlyView.Tan et al. developed a platelet membrane‐coated, thermoresponsive liposome for targeted, light‐controlled delivery of fluorinated peptides that promotes programmed death‐ligand 1 degradation, induces tumor immunogenic cell death, suppresses solid tumors and metastases, and triggers durable immune memory, offering a promising strategy for peptide‐based ...
Manman Tan +19 more
wiley +1 more source
Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1
Advanced Science, EarlyView.TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji +9 more
wiley +1 more source
Localization of the Rsp5p Ubiquitin-Protein Ligase at Multiple Sites within the Endocytic Pathway [PDF]
, 2001 Guangli Wang +5 more
openalex +1 more source