Results 181 to 190 of about 141,019 (215)

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley   +1 more source

Structural insights into CRL2FEM1C ubiquitin ligase-mediated protein ubiquitination. [PDF]

J Mol Cell Biol
Zhou H, Israel-Gueta M, Chen X, Guo Q, Liu X, Koren I, Xu C.   +6 more
europepmc   +1 more source

TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu, Ling‐Jung Yen, Hui‐Ling Hsia, Zi‐Xeng Weng, Chi‐Hsiang Chung, Paul Wei‐Che Hsu, Chih‐Wei Chiu, Wu‐Chien Chien, Tsung‐Hsien Chang   +8 more
wiley   +1 more source

E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling. [PDF]

JCI Insight
Han T, Wen X, Guo Y, Zhao X, Zhang J, Chen Y, Xu F.   +6 more
europepmc   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Identification and characterization of U-box E3 ubiquitin ligase genes (ChPUBs) in Cardamine hupingshanensis under abiotic stress. [PDF]

BMC Genomics
Wang Y, Yang F, Wan X, Yu Y, Tang L, Xie J, Xue H, Li Y, Xiang Z, Chen S, Tang Q, Hou Z, Zhou Y, Lu Y.   +13 more
europepmc   +1 more source

The E3 ubiquitin ligase Trip12 semi-selectively attenuates Wnt signaling. [PDF]

iScience
Ensing J, Ide AD, Gilliland C, Tsurho V, Rudisel E, Caza I, Stratman AN, Lanning NJ, Grainger S.   +8 more
europepmc   +1 more source

Balancing rice blast resistance and growth through suppression of the E3 ubiquitin ligase OsRING80. [PDF]

Plant Physiol
Hou X, You X, Mi X, Huang X, Hu H, Wang J, He F, Wang R, Wang S, Ning Y.   +9 more
europepmc   +1 more source

The membrane-associated ubiquitin ligase MARCHF8 degrades MHC-I in HPV-positive head and neck cancer for immune evasion. [PDF]

Proc Natl Acad Sci U S A
Khalil MI, Wang J, Vu L, Yang C, Yin C, Chadha S, Nabors H, Vocelle D, May DG, Chrisopulos RJ, Welbon CC, Zhou L, Roux KJ, Spanos WC, Bernard MP, Mi QS, Pyeon D.   +16 more
europepmc   +1 more source