Results 221 to 230 of about 254,188 (362)

Mammalian and bacterial adaptors function as co-disinhibitory pairs to activate the E3 ubiquitin ligase WWP2. [PDF]

J Biol Chem
Blundell SV, Liu M, Tocci R, Majstorovic A, Tsang S, Holden DW.   +5 more
europepmc   +1 more source

Modulating Parkin E3 Ubiquitin Ligase Activity Using Phospho-Ubiquitin Variants

, 2016
Susanna George
openalex   +1 more source

E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases

Li Zhu, Yongping Liu, YuanWang, Bin Sun, Yu-Ting Huang, Jikai Zhao, Jianfeng Liu, Li-Ming Yu, Huishan Wang   +8 more
openalex   +1 more source

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection [PDF]

, 2016
Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav I. Enchev, Matthias Peter, Raimundo Freire, Antônio Porro, Alessandro A. Sartori   +11 more
openalex   +1 more source

Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

Molecular and Cellular Biology, 2004
Donna D. Zhang, S. Lo, J. Cross, D. Templeton, M. Hannink   +4 more
semanticscholar   +1 more source

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1. [PDF]

Nat Commun
Orth B, Pohl P, Aust F, Ji Y, Seenivasan A, Dybkov O, Liang XJ, Bock L, Leidner F, Levantovsky S, Schardey P, Sander P, Disch NJ, Trautz ML, Mizi A, Papantonis A, Lenz C, Grubmüller H, Steinchen W, Behrends C, Urlaub H, Gehringer M, Lorenz S.   +22 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Structural insights into the human HRD1 ubiquitin ligase complex. [PDF]

Nat Commun
Guo L, Liu G, He J, Jia X, He Y, Wang Z, Qian H.   +6 more
europepmc   +1 more source

E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway

, 2011
Yingchun Li, Xiujuan Qu, Jinglei Qu, Zhang Ye, Jing Liu, Yuee Teng, Xuejun Hu, Kezuo Hou, Yunpeng Liu   +8 more
openalex   +2 more sources