Results 231 to 240 of about 327,531 (416)

Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

, 2000
Fumio Osaka, Mihoro Saeki, Satoshi Katayama, Noriko Aida, Akio Toh‐e, Kin‐ichiro Kominami, Takashi Toda, Toshiaki Suzuki, Tomoki Chiba, Keiji Tanaka, Seishi Kato   +10 more
openalex   +1 more source

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase [PDF]

, 2001
Ying E. Zhang, Chenbei Chang, Daniel J. Gehling, Ali Hemmati‐Brivanlou, Rik Derynck   +4 more
openalex   +1 more source

Cuproplasia and cuproptosis, two sides of the coin

Cancer Communications, EarlyView.
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu, Chandra Sugiarto Wijaya, Qinghua Yao, Hongchuan Jin, Lifeng Feng   +4 more
wiley   +1 more source

Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity [PDF]

, 2001
Heinz Ruffner, Claudio A.P. Joazeiro, Dan Hemmati, Tony Hunter, Inder M. Verma   +4 more
openalex   +1 more source

The Molecular Toolbox for Linkage Type‐Specific Analysis of Ubiquitin Signaling

ChemBioChem, EarlyView.
Ubiquitin modifications regulate virtually all aspects of eukaryotic cell biology through an array of polyubiquitin chain signals that adopt distinct structures, enabling the individual polyubiquitin linkages to mediate specific functions in cells.
Julian Koch, Camilla Reiter Elbæk, Dominik Priesmann, Rune Busk Damgaard   +3 more
wiley   +1 more source

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

Nature Structural &Molecular Biology, 2016
Ruth M. Densham, Alexander J. Garvin, Helen R. Stone, J. Strachan, R. Baldock, M. Daza-Martin, A. Fletcher, Sarah Blair-Reid, J. Beesley, Balraj Johal, L. Pearl, R. Neely, N. Keep, F. Z. Watts, Joanna R. Morris   +14 more
semanticscholar   +1 more source

Unveiling New Triazoloquinoxaline‐based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

Chemistry – A European Journal, Accepted Article.
PROteolysis Targeting Chimera (PROTAC) technology is an innovative and potent approach for achieving targeted protein degradation (TPD). Within bromodomain‐containing proteins, various degraders targeting BET family‐related targets, e.g., BRD4, were developed in the last years.
Martina Pierri, Guglielmo Bove, Erica Gazzillo, Ester Colarusso, Francesca Scala, Giacomo Pepe, Stefania Terracciano, Maria Giovanna Chini, Nicla Simonelli, Ines Bruno, Angela Nebbioso, Pietro Campiglia, Giuseppe Bifulco, Lucia Altucci, Nunzio Del Gaudio, Gianluigi Lauro   +15 more
wiley   +1 more source

Thymoquinone induces apoptosis in temozolomide‐resistant glioblastoma cells via the p38 mitogen‐activated protein kinase signaling pathway

Environmental Toxicology, Volume 38, Issue 1, Page 90-100, January 2023., 2023
Abstract Temozolomide (TMZ) can cross the blood‐brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair enzyme methyl guanine methyltransferase (MGMT), which removes methyl groups from purine bases, counteracts
Ai Mai, Shu‐Wen Ye, Jia‐Yu Tu, Jun Gao, Zhan‐Fang Kang, Qian‐Ming Yao, Wei‐Jen Ting   +6 more
wiley   +1 more source

The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex

Cell Reports, 2019
Summary: Adenoviruses (AdVs) cause respiratory, ocular, and gastrointestinal tract infection and inflammation in immunocompetent people and life-threatening disease upon immunosuppression.
Michael Bauer, Justin W. Flatt, Daria Seiler, Bettina Cardel, Mario Emmenlauer, Karin Boucke, Maarit Suomalainen, Silvio Hemmi, Urs F. Greber   +8 more
doaj  

Late‐stage Intermolecular O‐Peptidylation Protocol Enabled by Sequential Acyl Transfer on Thiol‐incorporated Threonine Followed by Desulfurization

Chemistry – A European Journal, Accepted Article.
The thiol functionality on the methyl group of a threonine derivative [Thr(SH)] facilitates O‐acylation of the Thr hydroxy group with a thioester. We previously showed that a Thr(SH)‐incorporated peptide thioester can be converted to the corresponding Thr‐containing cyclic depsipeptide through intramolecular thioester exchange (S−S acyl transfer) and ...
Daiki Sato, Rika Ota, Chiho Shinozaki, Masaya Denda, Akira Otaka   +4 more
wiley   +1 more source