Results 231 to 240 of about 349,913 (393)

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

A LjBAK1-associated E3 ubiquitin ligase, LjPUB7, negatively regulates early symbiosis by targeting NFRs. [PDF]

BMC Plant Biol
Feng Y, Zou Z, Liu C, Zhang D, Wang Y, Ma Y, Cao Y, Wu P.   +7 more
europepmc   +1 more source

14‐3‐3η is a novel regulator of parkin ubiquitin ligase [PDF]

, 2005
Shigeto Sato, Tomoki Chiba, Eri Sakata, Koichi Kato, Yoshikuni Mizuno, Nobutaka Hattori, Keiji Tanaka   +6 more
openalex   +1 more source

Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

Cell, 2015
Carlos T Pineda, Saumya Ramanathan, K. F. Tacer, J. Weon, Malia B. Potts, Yi-Hung Ou, M. White, P. R. Potts   +7 more
semanticscholar   +1 more source

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF‐1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression

Advanced Science, EarlyView.
Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun, Jieun Seo, Jiwon Koh, Seock‐Ah Im, Ki Yong Hong, Yeseon Son, Do‐Won Jeong, Junji Fukuda, Jong‐Wan Park, Yang‐Sook Chun   +9 more
wiley   +1 more source

Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer

Drug Design, Development and Therapy
Chunyan Weng,1,* Rijuan Jin,1,* Xiaoliang Jin,1,* Zimei Yang,1,* Chenghai He,1,2 Qiuhua Zhang,1 Jingli Xu,1,3 Bin Lv1 1Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang ...
Weng C, Jin R, Jin X, Yang Z, He C, Zhang Q, Xu J, Lv B   +7 more
doaj  

The ubiquitin ligase RCBTB2 regulates aggrephagy and inhibits prostate cancer progression by targeting GPAA1 for degradation. [PDF]

Am J Cancer Res
Mo R, Chi N, Du J, Li X, Guo W, Li H, Wang J, Cai C, Li S, Liu C.   +9 more
europepmc   +1 more source

The RING ‐finger E3 ubiquitin ligase SlMIEL1 interacts with SlNAC35 to regulate JA biosynthesis and mediate saline‐alkali stress responses in tomato [PDF]

Xiangguang Meng, Zhen Kang, Yong Zhang, Quan‐Lin Li, Changan Zhu, Tianlai Li, Guobin Li, Xiaohui Hu   +7 more
openalex   +1 more source

The Stability of Histone Acetyltransferase General Control Non-derepressible (Gcn) 5 Is Regulated by Cullin4-RING E3 Ubiquitin Ligase [PDF]

, 2011
Yongming Li, Aimee Jaramillo-Lambert, Jing Hao, Yi Yang, Wenge Zhu   +4 more
openalex   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source