Results 261 to 270 of about 232,343 (304)

Ubiquitin Ligases in Malignant Lymphoma

Leukemia & Lymphoma, 2004
The highly controlled degradation of proteins via the ubiquitin-proteasome pathway represents a key mechanism for cell regulation and homeostasis. Ubiquitin-dependent proteolysis, carried out in large part by the E3 ubiquitin ligases, is a critical mode of post-translational modification that is important in regulation of cell cycle progression, signal
Megan S, Lim, Kojo S J, Elenitoba-Johnson   +1 more
openaire   +2 more sources

Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases

2019
Ubiquitination is a reversible process that controls the intracellular transport of many transmembrane molecules. Ubiquitination of MHC I, MHC II, and CD1a by different members of the MARCH family of E3 ubiquitin ligases is a key event in the regulation of the potent immunostimulatory properties of activated dendritic cells. We describe here methods to
openaire   +2 more sources

Comprehensive Ubiquitin E2 Profiling of Ten Ubiquitin E3 Ligases

Cell Biochemistry and Biophysics, 2013
The ubiquitin pathway regulates diverse functions including protein localization and stability. The complexity of the pathway involving nearly 40 identified E2 conjugating enzymes and over 600 E3 ligases raises the issue of specificity. With the E2s and E3s fitting into a limited number of classes based on bioinformatics, structures, and proven ...
Jeffrey G, Marblestone, Samir, Butt, Devin M, McKelvey, David E, Sterner, Michael R, Mattern, Benjamin, Nicholson, Michael J, Eddins   +6 more
openaire   +2 more sources

Parkin: a multifaceted ubiquitin ligase

Biochemical Society Transactions, 2006
Mutations in the parkin gene are a common cause of autosomal recessive early-onset parkinsonism. Parkin functions as an E3 ubiquitin ligase where it can polyubiquitinate a number of its protein substrates, thus targeting them for degradation by the 26 S proteasomal complex.
openaire   +2 more sources

Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy

Circulation Research
BACKGROUND: Clearance of damaged mitochondria via mitophagy is crucial for cellular homeostasis. Apart from Parkin, little is known about additional Ub (ubiquitin) ligases that mediate mitochondrial ubiquitination and turnover, particularly in highly metabolically active organs such as the heart.
Wenjuan Wang, Ermin Li, Jianqiu Zou, Chen Qu, Juan Ayala, Yuan Wen, Md Sadikul Islam, Neal L. Weintraub, David J.R. Fulton, Qiangrong Liang, Jiliang Zhou, Jinbao Liu, Jie Li, Yi Sun, Huabo Su   +14 more
openaire   +3 more sources

Lipidating a ubiquitin ligase

Science Signaling, 2019
A previously undescribed enzyme promotes lipidation of a ubiquitin ligase that regulates PI3K and Ca 2+ signaling.
openaire   +1 more source

An expanded lexicon for the ubiquitin code

Nature Reviews Molecular Cell Biology, 2022
Ivan Đikić, Brenda A Schulman
exaly  

Ubiquitin ligases: guardians of mammalian development

Nature Reviews Molecular Cell Biology, 2022
David A Cruz Walma, Zhuoyao Chen, Alex N Bullock   +2 more
exaly  

Ubiquitin-calmodulin ligase

1998
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Building and decoding ubiquitin chains for mitophagy

Nature Reviews Molecular Cell Biology, 2018
Alban Ordureau, Jin-Mi Heo
exaly