Results 261 to 270 of about 327,531 (416)

The DSmurf Ubiquitin-Protein Ligase Restricts BMP Signaling Spatially and Temporally during Drosophila Embryogenesis [PDF]

, 2001
Steven D. Podos, Kirsten K. Hanson, Yu-Chiun Wang, Edwin L. Ferguson   +3 more
openalex   +1 more source

Sustainable Synthesis of 1,2,3‐Triazoles using Cyrene as a Biodegradable Solvent in Click Chemistry

ChemSusChem, EarlyView.
Green triazoles: The first successful synthesis of 1,2,3‐triazoles using Cyrene as a biodegradable and non‐toxic solvent in click chemistry has been developed. This sustainable approach allows product isolation by simple precipitation in water, eliminating the need for organic solvent extractions and chromatographic purifications, thus minimizing waste
Andrea Citarella, Alessandro Fiori, Alessandra Silvani, Daniele Passarella, Valerio Fasano   +4 more
wiley   +1 more source

The transcriptional profile of iron deficiency in patients with heart failure: Heme‐sparing and reduced immune processes

European Journal of Heart Failure, EarlyView.
The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%)
Niels Grote Beverborg, Ridha I.S. Alnuwaysir, George Markousis‐Mavrogenis, Martijn F. Hoes, Haye H. van der Wal, Simon P.R. Romaine, Mintu Nath, Andrea Koekoemoer, John G.F. Cleland, Chim C. Lang, Stefan D. Anker, Kenneth Dickstein, Marco Metra, Leong L. Ng, Dirk J. van Veldhuisen, Adriaan A. Voors, Nilesh J. Samani, Peter van der Meer   +17 more
wiley   +1 more source

The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins. [PDF]

J Biol Chem
Liu D, Huo XY, Zhang X, Zhang ZR.
europepmc   +1 more source

Localization of the Rsp5p Ubiquitin-Protein Ligase at Multiple Sites within the Endocytic Pathway [PDF]

, 2001
Guangli Wang, J. Michael McCaffery, Beverly Wendland, Sophie Dupré‐Crochet, Rosine Haguenauer‐Tsapis, Jon M. Huibregtse   +5 more
openalex   +1 more source

Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer

Exploration, EarlyView.
In this study, A04, a compound targeting the degradation of metabolic enzyme PDK1, was developed by PROTAC technology, which significantly inhibited tumor proliferation by disrupting the Warburg effect in cancer cells. In the mouse model, A04 could prolong postoperative survival, and also remodel the immunosuppressive microenvironment, which could ...
Aohua Deng, Renming Fan, Jiakui Gou, Ruoxi Sang, Ruizhuo Lin, Ting Zhao, Junyan Zhuang, Yongrui Hai, Jialin Sun, Gaofei Wei   +9 more
wiley   +1 more source

The E3 Ubiquitin Ligase PRAJA1: A Key Regulator of Synaptic Dynamics and Memory Processes with Implications for Alzheimer's Disease. [PDF]

Int J Mol Sci
Li C, Yan Y, Stork O, Shen R, Behnisch T.   +4 more
europepmc   +1 more source

Characterization of Functional Domains of Cul3, an E3 Ubiquitin Ligase, Using Chimeric Analysis

, 2000
Jennifer Mitchell
openalex   +2 more sources

Lung Krüppel-like Factor Contains an Autoinhibitory Domain That Regulates Its Transcriptional Activation by Binding WWP1, an E3 Ubiquitin Ligase [PDF]

, 2001
Michael D. Conkright, Maqsood A. Wani, Jerry B. Lingrel   +2 more
openalex   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source