Results 321 to 330 of about 349,913 (393)

The E3 ubiquitin ligase adaptor KLHL8 targets ZAR1 to regulate maternal mRNA degradation in oocytes. [PDF]

EMBO Rep
Fan H, Liu R, Yu R, Chen B, Li Q, Mu J, Wang W, Wu T, He L, Wang L, Sang Q, Zhang Z.   +11 more
europepmc   +1 more source

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

ESC Heart Failure, EarlyView.
Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori, Sergio Davinelli, Armando Ferrera, Alessandro Medoro, Carlo Barsali, Allegra Battistoni, Maurizio Volterrani, Massimo Volpe, Luciano Saso, Speranza Rubattu   +9 more
wiley   +1 more source

Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai. [PDF]

Cell Mol Biol Lett
Escuder-Rodríguez JJ, Rodríguez-Alonso A, Jove L, Quiroga M, Alfonsín G, Figueroa A.   +5 more
europepmc   +1 more source

The transcriptional profile of iron deficiency in patients with heart failure: Heme‐sparing and reduced immune processes

European Journal of Heart Failure, EarlyView.
The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%)
Niels Grote Beverborg, Ridha I.S. Alnuwaysir, George Markousis‐Mavrogenis, Martijn F. Hoes, Haye H. van der Wal, Simon P.R. Romaine, Mintu Nath, Andrea Koekoemoer, John G.F. Cleland, Chim C. Lang, Stefan D. Anker, Kenneth Dickstein, Marco Metra, Leong L. Ng, Dirk J. van Veldhuisen, Adriaan A. Voors, Nilesh J. Samani, Peter van der Meer   +17 more
wiley   +1 more source

The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth. [PDF]

Neural Regen Res
Cai Z, Wu H, Jiang T, Ma A, Meng Z, Zhu J, Lin H, Liang Y, Zhang G, Tan M.   +9 more
europepmc   +1 more source

An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina. [PDF]

PLoS Pathog
Wang H, Zhang J, Liu R, Li Y, Du Y, Wei T.   +5 more
europepmc   +1 more source

The <i>Arabidopsis</i> E3 ubiquitin ligase PUB13 synergistically interacts with BON1 to regulate plant flowering and immunity. [PDF]

Front Plant Sci
Yue J, Zou X, Peng Y, Pan S, Hu C, Wang B, Dai L, Li W.   +7 more
europepmc   +1 more source

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213. [PDF]

Nat Commun
Ahel J, Balci A, Faas V, Grabarczyk DB, Harmo R, Squair DR, Zhang J, Roitinger E, Lamoliatte F, Mathur S, Deszcz L, Bell LE, Lehner A, Williams TL, Sowar H, Meinhart A, Wood NT, Clausen T, Virdee S, Fletcher AJ.   +19 more
europepmc   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β-TrCP-Mediated IFNAR1 Degradation. [PDF]

Adv Sci (Weinh)
Wan Q, Zhu L, Chen C, Zhong L, Leung H, Li W, Xu C, Yao X, Hu H, Wu M, Hou Y, Chu H, Wang Y, Chen S, Pan M, Cai Z, He ML.   +16 more
europepmc   +1 more source

Ubiquitin Ligase Gene <i>OsPUB57</i> Negatively Regulates Rice Blast Resistance. [PDF]

Plants (Basel)
Zhang J, Du Q, Wu Y, Shen M, Gao F, Wang Z, Xiao X, Tang W, Chen Q.   +8 more
europepmc   +1 more source