Results 321 to 330 of about 327,531 (416)

The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development. [PDF]

Nat Commun
Hwang S, Park J, Koo SY, Lee SY, Jo Y, Ryu D, Go H, Lee CW.   +7 more
europepmc   +1 more source

Different nontarget‐site mechanisms underlie resistance to dicamba and 2,4‐D in an Amaranthus tuberculatus population

Pest Management Science, EarlyView.
Weak phenotypic and genetic associations between resistance to dicamba and 2,4‐D suggest that different nontarget‐site mechanisms contribute to these traits in an Amaranthus tuberculatus population from Illinois. Abstract BACKGROUND Amaranthus tuberculatus (Moq.) Sauer (waterhemp) has emerged as one of several weed species that is resistant to ...
Isabel Schlegel Werle, Lucas Kopecky Bobadilla, Damilola A Raiyemo, Alexander J Lopez, Filipi Mesquita Machado, Patrick J Tranel   +5 more
wiley   +1 more source

HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response. [PDF]

EMBO Rep
Nishimura S, Kioka H, Ding S, Hakui H, Shinomiya H, Tanabe K, Hitsumoto T, Matsuoka K, Kato H, Tsukamoto O, Asano Y, Takashima S, Enchev RI, Sakata Y.   +13 more
europepmc   +1 more source

A point mutation in IAA34 confers resistance to the auxin herbicide 2,4‐D in Sisymbrium orientale

Pest Management Science, EarlyView.
A point mutation in domain IV of SoAux/IAA34‐R provides resistance to 2,4‐D. Abstract BACKGROUND Sisymbrium orientale has evolved resistance to 2,4‐D in Australia due to a 27 bp deletion in SoIAA2. However, one population of Sisymbrium orientale resistant to 2,4‐D (R1) did not contain the SoIAA2Δ27, suggesting another 2,4‐D resistance mechanism was ...
Yuanlin Qi, Mahima Krishnan, Matthew Tucker, Christopher Preston   +3 more
wiley   +1 more source

PDLIM2 is a novel E5 ubiquitin ligase enhancer that stabilizes ROC1 and recruits the ROC1-SCF ubiquitin ligase to ubiquitinate and degrade NF-κB RelA. [PDF]

Cell Biosci
Sun F, Xiao G, Qu Z.
europepmc   +1 more source

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.

Cancer Cell, 2014
Ryan J. Davis, M. Welcker, B. Clurman
semanticscholar   +1 more source

TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity.

Journal of Molecular Biology, 2014
Ricardo Rajsbaum, A. García-Sastre, Gijs A. Versteeg   +2 more
semanticscholar   +1 more source

Liposome‐Polymer Nanoparticles Loaded with Copper Diethyldithiocarbamate and 6‐Bromo‐Indirubin‐3′‐Oxime Enable the Treatment of Refractive Melanoma

Small, EarlyView.
Cancer cells are exposed to heightened levels of endoplasmic reticulum stress and inflammation within the tumor microenvironment which can lead to therapeutic resistance. To address this issue, liposome‐polymer nanoparticles loaded with copper diethyldithiocarbamate (CuET), a potent inhibitor of the p97‐UFD1‐NPL4 protein complex, and the anti ...
Radu A. Paun, Ling Li, Adam Mouncef, Danuta Radzioch, Maryam Tabrizian   +4 more
wiley   +1 more source

Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB. [PDF]

Commun Biol
Kang SW, Park JE, Ok S, Um M, Son H, Byun S, Park N, Lee SJ, Trần TXT, Kim G, Yeom J, Kim K, Kim EY, Kang MJ.   +13 more
europepmc   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source