Results 341 to 350 of about 349,913 (393)

Lipidating a ubiquitin ligase

Science Signaling, 2019
A previously undescribed enzyme promotes lipidation of a ubiquitin ligase that regulates PI3K and Ca 2+ signaling.
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Vimentin is a ubiquitination and degradation substrate of the ubiquitin ligase KPC1

Biochemical and Biophysical Research Communications
The ubiquitin proteasome system (UPS), driven by ubiquitin as a degradation signal, eliminates, in a highly specific manner, 'abnormal' proteins and proteins that completed their function. This process involves a hierarchical cascade of E1, E2, and E3 enzymes. The E3 ubiquitin ligases, act as specific receptors that bind their cognate substrates.
Yossi Gottfried, Chen Lulu-Shimron, Gilad Goldhirsh, Yael Fisher, Tamar Ziv, Dave S.B. Hoon, Yelena Kravtsova-Ivantsiv, Aaron Ciechanover   +7 more
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Ubiquitin Ligases and Cancer

2009
Ubiquitin E3 ligases are the most prevalent cancer genes besides protein kinases, suggesting a critical role in cancer development and progression. Two major classes of E3 ligases can be distinguished: the HECT-type and the adaptor-type E3s. The latter include RING-finger, PHD, and U-box domain ligases.
Angelika M. Burger, Arun K. Seth
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Assembly and Regulation of CRL Ubiquitin Ligases

2020
Cullin-RING ubiquitin ligases (CRLs) determine the substrate specificity of ubiquitination reactions, and substrates are recruited to the cullin core through binding to their cognate substrate receptor modules. Because a family of substrate receptors compete for the same cullin core, the assembly and activity of CRLs are dynamically regulated to ...
Kankan, Wang, Raymond J, Deshaies, Xing, Liu   +2 more
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E3 ubiquitin ligases for MHC molecules

Current Opinion in Immunology, 2009
Recently, novel E3 ubiquitin ligases that target MHC molecules for lysosomal degradation have been discovered by several groups. All these E3s are membrane-bound and possess a variant type RING domain, termed the RING-CH or RING variant (RINGv) domain. They belong to a new E3 family designated Modulator of Immune Recognition (MIR), based on the name of
Satoshi, Ishido, Eiji, Goto, Yohei, Matsuki, Mari, Ohmura-Hoshino   +3 more
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Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy

Circulation Research
BACKGROUND: Clearance of damaged mitochondria via mitophagy is crucial for cellular homeostasis. Apart from Parkin, little is known about additional Ub (ubiquitin) ligases that mediate mitochondrial ubiquitination and turnover, particularly in highly metabolically active organs such as the heart.
Wenjuan Wang, Ermin Li, Jianqiu Zou, Chen Qu, Juan Ayala, Yuan Wen, Md Sadikul Islam, Neal L. Weintraub, David J.R. Fulton, Qiangrong Liang, Jiliang Zhou, Jinbao Liu, Jie Li, Yi Sun, Huabo Su   +14 more
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A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

Nature, 2016
M. Matyskiela, Gang Lu, Takumi Ito, B. Pagarigan, Chin-Chun Lu, Karen Miller, W. Fang, Nai-Yu Wang, Derek Nguyen, J. Houston, G. Carmel, T. Tran, Mariko Riley, Lyn’Al Nosaka, G. Lander, S. Gaidarova, Shuichan Xu, Alexander L. Ruchelman, H. Handa, J. Carmichael, Thomas O. Daniel, B. Cathers, A. Lopez-Girona, P. Chamberlain   +23 more
semanticscholar   +1 more source

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

Nature, 2016
G. Petzold, E. Fischer, N. Thomä
semanticscholar   +1 more source

Role of Ubiquitin and Ubiquitin Ligases in Retroviral Budding

2010
A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns

Nature Structural & Molecular Biology, 2018
H. Walden, K. Rittinger
semanticscholar   +1 more source