Results 341 to 350 of about 327,531 (416)

Molecular insights into degron recognition by CRL5^ASB7 ubiquitin ligase. [PDF]

Nat Commun
Zhou M, Wang X, Li J, Ma J, Bao Z, Yan X, Zhang B, Liu T, Yu Y, Mi W, Dong C.   +10 more
europepmc   +1 more source

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

, 2002
Wanping Xu, Monica G. Marcu, Xitong Yuan, Edward G. Mimnaugh, Cam Patterson, Len Neckers   +5 more
openalex   +1 more source

CALB1 and RPL23 Are Essential for Maintaining Oocyte Quality and Function During Aging

Aging Cell, EarlyView.
This study investigates the mechanisms of oocyte aging in mice, identifying Calb1 and Rpl23 as key genes involved in calcium ion homeostasis and mitochondrial function. Knockdown of these genes led to mitochondrial dysfunction, meiotic defects, and spindle assembly abnormalities, while their overexpression partially rescued age‐related oocyte defects ...
Yingxue Han, Zihuan Du, Hao Wu, Rong Zhao, Jikang Liu, Shuai Gao, Shenming Zeng   +6 more
wiley   +1 more source

GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function. [PDF]

Mol Cancer Res
Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D.   +16 more
europepmc   +1 more source

From Clinical to Benchside: Lacticaseibacillus and Faecalibacterium Are Positively Associated With Muscle Health and Alleviate Age‐Related Muscle Disorder

Aging Cell, EarlyView.
Old people with or without sarcopenia exhibited different gut microbiota and metabolite compositions. Mice receiving microbes from people with sarcopenia displayed lower muscle mass and strength compared with those receiving microbes from non‐sarcopenic donors.
Chaoran Liu, Pui Yan Wong, Nilakshi Barua, Baoqi Li, Hei Yuet Wong, Ning Zhang, Simon Kwoon Ho Chow, Sunny Hei Wong, Jun Yu, Margaret Ip, Wing Hoi Cheung, Gustavo Duque, Christoph Brochhausen, Joseph Jao Yiu Sung, Ronald Man Yeung Wong   +14 more
wiley   +1 more source

The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature. [PDF]

EMBO J
Sakamoto Y, Uezu A, Kikuchi K, Kang J, Fujii E, Moroishi T, Suetsugu S, Nakanishi H.   +7 more
europepmc   +1 more source

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

Aging Cell, EarlyView.
This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A. [PDF]

EMBO J
Hao X, Hu Z, Li M, Zhang S, Tang M, Hao C, Qi S, Liang Y, Almeida MF, Smith K, Zuo C, Feng Y, Guo M, Ma D, Li S, Wang Z, Sun Y, Deng Z, Mao C, Xia Z, Jiang Y, Gao Y, Xu Y, Schisler JC, Shi C.   +24 more
europepmc   +1 more source

Cathepsin B Regulates Ovarian Reserve Quality and Quantity via Mitophagy by Modulating IGF1R Turnover

Aging Cell, EarlyView.
Autophagy regulates ovarian reserve, with Cathepsin B playing a critical role in aging. Inhibition of Cathepsin B increases follicle count, enhances IGF1R–AKT–mTOR signaling and improves mitochondrial function without compromising fertility. This conserved mechanism suggests potential therapeutic strategies to delay ovarian aging and sustain fertility,
Aradhana Mohanty, Anjali Kumari, Lava Kumar. S, Ajith Kumar, Pravin Birajdar, Rohit Beniwal, Mohd Athar, Kiran Kumar. P, H.B.D.Prasada Rao   +8 more
wiley   +1 more source