Results 1 to 10 of about 3,024 (62)
Chronic rhinosinusitis: assessment of changes in nociceptive neurons
International Forum of Allergy &Rhinology, Volume 10, Issue 10, Page 1165-1172, October 2020., 2020 Background Pain is a major symptom of chronic rhinosinusitis (CRS). It is mainly associated with CRS without nasal polyps (CRSsNP) and has a major impact in the decision to move on to surgery. Patients with CRS with nasal polyps (CRSwNP) are characterized by trigeminal hypoesthesia and suffer from less pain.
Stijn Bogaert +6 more
wiley +1 more source
New Phytologist, Volume 201, Issue 4, Page 1227-1239, March 2014., 2014 Summary Increasing demands for food and energy require a step change in the effectiveness, speed and flexibility of crop breeding. Therefore, the aim of this study was to assess the potential of genome‐wide association studies (GWASs) and genomic selection (i.e.
Gancho T. Slavov +8 more
wiley +1 more source
Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
The Scientific World Journal, Volume 2014, Issue 1, 2014., 2014 Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment
Petra Hudler +4 more
wiley +1 more source
Could Upregulated Hsp70 Protein Compensate for the Hsp90‐Silence‐Induced Cell Death in Glioma Cells?
International Journal of Brain Science, Volume 2014, Issue 1, 2014., 2014 The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17‐allylamino‐17‐demethoxygeldanamycin (17AAG) and a short hairpin RNA (shRNA) oligonucleotide targeting hsp90α (shhsp90α) in the U87 ...
Chinmay Munje +4 more
wiley +1 more source
The FEBS Journal, Volume 280, Issue 18, Page 4474-4494, September 2013., 2013 Alterations in cell shape affect endothelial cell function, yet it is unknown how morphological restriction affects the transcriptome. We cultured endothelial cells on spatially defined adhesive micropatterns and used pattern recognition algorithms, statistical analysis, and microarray data to demonstrate that the ability of endothelial cells to spread,
Jessica M. Stiles +7 more
wiley +1 more source
Meta-analysis of cancer transcriptomes: A new approach to uncover molecular pathological events in different cancer tissues [PDF]
Network Biology, 2014 To explore secrets of metastatic cancers, individual expression of true sets of respective genes must spread across the tissue. In this study, meta-analysis for transcriptional profiles of oncogenes was carried out to hunt critical genes or networks ...
Sundus Iqbal +2 more
doaj
The Scientific World Journal, Volume 2013, Issue 1, 2013., 2013 Schizophrenia affecting almost 1% and bipolar disorder affecting almost 3%–5% of the global population constitute two severe mental disorders. The catecholaminergic and the serotonergic pathways have been proved to play an important role in the development of schizophrenia, bipolar disorder, and other related psychiatric disorders. The aim of the study
Marianthi Logotheti +7 more
wiley +1 more source
The Plant Genome, Volume 3, Issue 1, July 2010., 2010 Few quantitative trait loci (QTL) have been mapped for the expression of partial resistance to Phytophthora sojae in soybean and very little is known about the molecular mechanisms that contribute to this trait. Therefore, the objectives of this study were to identify additional QTL conferring resistance to P. sojae and to identify candidate genes that
Hehe Wang +11 more
wiley +1 more source
Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer′s Disease
International Journal of Alzheimer’s Disease, Volume 2010, Issue 1, 2010., 2010 Various animal models of Alzheimer′s disease (AD) have been created to assist our appreciation of AD pathophysiology, as well as aid development of novel therapeutic strategies. Despite the discovery of mutated proteins that predict the development of AD, there are likely to be many other proteins also involved in this disorder.
Wayne Chadwick +4 more
wiley +1 more source
Biomarkers and clinical rules for the management of mild traumatic brain injury: a narrative review
International Journal of Emergency MedicineBackground Mild traumatic brain injury (mTBI) accounts for 80% of TBI cases. Although only 16% show intracranial lesions and
Sebastián Salgado +5 more
doaj +1 more source