Results 21 to 30 of about 101,303 (167)

Emerging functions of branched ubiquitin chains

Cell Discovery, 2021
Ubiquitylation is a critical post-translational modification that controls a wide variety of processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different cellular functions and control the stability, activity ...
Michael E. French, Chad F. Koehler, T. Hunter   +2 more
semanticscholar   +1 more source

Ubiquitin System

International Journal of Molecular Sciences, 2018
Ever since the discovery of ubiquitin in 1975[...].
N. Nakamura
semanticscholar   +1 more source

Structural Diversity of Ubiquitin E3 Ligase

Molecules, 2021
The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
S. Toma-Fukai, Toshiyuki Shimizu
semanticscholar   +1 more source

Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease [PDF]

, 2007
Gene expression profiling is a powerful method by which alterations in gene expression can be interrogated in a single experiment. The disease familial adenomatous polyposis (FAP) is associated with germline mutations in the APC gene, which result in ...
Nikola A Bowden, Amanda Croft, Rodney J Scott   +2 more
core   +1 more source

Cellular quality control by the ubiquitin-proteasome system and autophagy

Science, 2019
To achieve homeostasis, cells evolved dynamic and self-regulating quality control processes to adapt to new environmental conditions and to prevent prolonged damage.
C. Pohl, I. Dikič
semanticscholar   +1 more source

Ubiquitin–proteasome system (UPS) as a target for anticancer treatment

Archives of pharmacal research, 2020
The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer.
Jinyoung Park, Jinhong Cho, E. J. Song
semanticscholar   +1 more source

An integrative multi-platform analysis for discovering biomarkers of osteosarcoma [PDF]

, 2009
Background SELDI-TOF-MS (Surface Enhanced Laser Desorption/Ionization-Time of Flight-Mass Spectrometry) has become an attractive approach for cancer biomarker discovery due to its ability to resolve low mass proteins and high-throughput capability ...
Guodong Li, Wenjuan Zhang, Huazong Zeng, Lei Chen, Wenjing Wang, Jilong Liu, Zhiyu Zhang, Zhengdong Cai, X Deng, M Sztán, DC Dahlin, WF Enneking, S Jin, T Philip, G Bacci, Y Li, EP Diamandis, JM Sorace, KA Baggerly, T Pisitkun, LC Whelan, Y Benjamini, DA Hosack, A Bairoch, E Gasteiger, B Boeckmann, M Tafani   +26 more
core   +1 more source

RNA-seq analysis of the gonadal transcriptome during Alligator mississippiensis temperature-dependent sex determination and differentiation [PDF]

, 2016
Annotation of development-dependent dimorphic genes in gonad during Day 0–12. Annotation of development-dependent significantly up- and down- regulated DEGs at FDR 
Benjamin B. Parrott, Hitoshi Miyakawa, Katsushi Yamaguchi, Louis J. Guillette, Russell H. Lowers, Ryohei Yatsu, Satomi Kohno, Shinichi Miyagawa, Shuji Shigenobu, Taisen Iguchi, Yukiko Ogino   +10 more
core   +7 more sources

Genetic and epigenetic landscape of nasopharyngeal carcinoma [PDF]

, 2016
published_or_final_versio
Cheung, AKL, Dai, W, Lung, ML, ZHENG, H
core   +1 more source

NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly

Nature, 2020
Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein ubiquitylation 1 , which is tightly controlled by the modification of cullin with the ubiquitin-like protein NEDD8 2 – 6 . However, how CRLs catalyse ubiquitylation, and the
Kheewoong Baek, David T. Krist, J. R. Prabu, Spencer Hill, Maren Klügel, Lisa-Marie Neumaier, S. von Gronau, Gary Kleiger, B. Schulman   +8 more
semanticscholar   +1 more source