Employing machine learning for reliable miRNA target identification in plants [PDF]
, 2011 Background miRNAs are ~21 nucleotide long small noncoding RNA molecules, formed endogenously in most of the eukaryotes, which mainly control their target genes post transcriptionally by interacting and silencing them.
Ashwani Jha, Ravi Shankar
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Cell Research, 2016 Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a ...
Kirby N. Swatek, D. Komander
semanticscholar +1 more source
Ubiquitin signaling in cell cycle control and tumorigenesis
Cell Death and Differentiation, 2020 Cell cycle progression is a tightly regulated process by which DNA replicates and cell reproduces. The major driving force underlying cell cycle progression is the sequential activation of cyclin-dependent kinases (CDKs), which is achieved in part by the
Fabin Dang, Li Nie, Wenyi Wei
semanticscholar +1 more source
A Bioinformatics Approach [PDF]
, 2015 By regulating the timing of cellular processes, the circadian clock provides a way to adapt physiology and behaviour to the geophysical time. In mammals, a light-entrainable master clock located in the suprachiasmatic nucleus (SCN) controls peripheral ...
Abreu, Monica +7 more
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Specific age related signatures in Drosophila body parts transcriptome. [PDF]
, 2006 BACKGROUND: During the last two decades progress in the genetics of aging in invertebrate models such as C. elegans and D. melanogaster has clearly demonstrated the existence of regulatory pathways that control the rate of aging in these organisms, such ...
Girardot, Fabrice +3 more
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Nature, 2015 Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains ...
M. Lazarou +8 more
semanticscholar +1 more source
Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis [PDF]
, 2007 Background Amyotrophic lateral sclerosis (ALS) is a fatal disorder caused by the progressive degeneration of motoneurons in brain and spinal cord. Despite identification of disease-linked mutations, the diversity of processes involved and the ambiguity ...
Santama Niovi +4 more
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Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie [PDF]
, 2014 Background: Prion diseases are characterized by the accumulation of the pathogenic PrPSc protein, mainly in the brain and the lymphoreticular system.
Badiola, J.J. +9 more
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Comparative transcriptome analysis and marker development of two closely related Primrose species (Primula poissonii and Primula wilsonii) [PDF]
, 2013 BACKGROUND: Primula species are important early spring garden plants with a centre of diversity and speciation in the East Himalaya-Hengduan Mountains in Western China. Studies on population genetics, speciation and phylogeny of Primula have been impeded
Hai-Fei Yan +4 more
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Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Prediction of Computed Tomography Findings in Traumatic Brain Injury; a Meta-Analysis [PDF]
, 2018 Introduction: Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is one of the promising candidates, with an acceptable diagnostic value for predicting head computed tomography (CT) scan findings.
Babahajian, Asrin +4 more
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