Results 121 to 130 of about 117,949 (359)
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol+3 more
wiley +1 more source
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu+15 more
wiley +1 more source
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian+18 more
wiley +1 more source
The schematic diagram illustrates the role of the recruitment of Gal3‐CaN‐Smurf1 complex in maintaining lysosomal membrane homeostasis upon damage. On the one hand, the Gal3‐CaN‐Smurf1 complex sequesters FLCN‐FNIPs to block the activation of RagC, where the active form RagC‐GDP is responsible for TFEB phosphorylation.
Qin Xia+10 more
wiley +1 more source
Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent [PDF]
Yael Rosenberg‐Hasson+3 more
openalex +1 more source
The role of ubiquitin ligases in the control of organ specific autoimmunity [PDF]
Diabetes mellitus is characterized by chronic hyperglycemia caused by a deficiency in insulin action, insulin secretion or both. Type 1 diabetes is classified as the destruction of beta cells leading to a deficiency in insulin production.
Hoyne, Gerard F
core +2 more sources
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian+15 more
wiley +1 more source
Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin‐dependent and is accompanied by a high rate of ATP hydrolysis [PDF]
S. Rapoport+2 more
openalex +1 more source
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie+10 more
wiley +1 more source
Epithelial to mesenchymal transition in the pathogenesis of uterine malignant mixed Müllerian tumours: the role of ubiquitin proteasome system and therapeutic opportunities [PDF]
Malignant mixed Müllerian tumours (malignant mixed mesodermal tumours, MMMT) of the uterus are metaplastic carcinomas with a sarcomatous component and thus they are also called carcinosarcomas.
Voutsadakis, Ioannis
core