Results 121 to 130 of about 117,989 (312)

Clinical Neuropathology teaching case 3-2015: female or male brain? Anti-ubiquitin visualizes Barr bodies in hippocampal granule cells which allows the determination of gender in human brains

, 2015
Ellen Gelpí
openalex   +2 more sources

Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches [PDF]

, 2007
Vsevolod Katritch, Chelsea M. Byrd, Vladimir M. Tseitin, Dongcheng Dai, Eugene Raush, Maxim Totrov, Ruben Abagyan, Robert Jordan, Dennis E. Hruby   +8 more
openalex   +1 more source

Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
openaire   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48. [PDF]

Mol Cell, 2023
Williams C, Dong KC, Arkinson C, Martin A.   +3 more
europepmc   +1 more source

Dysregulation of CircZNF79(5) Modulates YBX1 Stability and Selective Autophagy to Drive Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
In HCC, circZNF79(5) binds to YBX1 and functions as an oncogene, recruits BRCC36 to remove K63‐linked ubiquitin chains to stabilize YBX1 protein, and promotes HCC progression via the HIF‐1 signaling pathway. Conversely, circZNF79(5) silencing activates the AMPK/mTOR pathway, inducing p62‐mediated selective autophagic degradation of YBX1.
Xueqiang Guo, Lingling Xi, Yukun Liu, Wenbao Lv, Tianzi Li, Andong Ju, Zhenlin Fan, Yaping Shen, Zhuang Qian, Weiyun Wang, Zhuo Liang, Wenjuan Song, Kaiwen Chang, Shuangping Ma, Junhe Zhang, Tao Han, Kun You, Cunshuan Xu, Lei Wang, Weisheng Guo, Wenjie Ren   +20 more
wiley   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Down-Regulation of Ubiquitin-Specific Peptidase 9X Inhibited Proliferation, Migration and Invasion of Osteosarcoma <i>via</i> ERK1/2 and PI3K/Akt Signaling Pathways

, 2022
Wendi Zheng, Shuang Li, Jincheng Huang, Yonghui Dong, Hongjun Zhang, Jia Zheng   +5 more
openalex   +2 more sources

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source