Results 131 to 140 of about 117,989 (312)

Unusually Divergent Ubiquitin Genes and Proteins in Plasmodium Species. [PDF]

Genome Biol Evol, 2023
Dalhuisen T, Plenderleith LJ, Ursani I, Philip N, Hahn BH, Sharp PM.   +5 more
europepmc   +1 more source

Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis

, 2019
Teresa M. Gunn, Derek Silvius, Andrew Lester, Britney Gibbs   +3 more
openalex   +2 more sources

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

Oncogene, 2004
M. Marmor, Y. Yarden
semanticscholar   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Structural basis for adenylation and thioester bond formation in the ubiquitin E1 [PDF]

, 2019
Z.S. Hann, Cheng Ji, Shaun K. Olsen, Xuequan Lu, Michaelyn C. Lux, Derek S. Tan, Christopher D. Lima   +6 more
openalex   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Preparation of site-specifically fluorophore-labeled polyubiquitin chains for FRET studies of Cdc48 substrate processing. [PDF]

STAR Protoc, 2023
Williams C, Dong KC, Arkinson C, Martin A.   +3 more
europepmc   +1 more source

Biochemical properties and in planta effects of NopM, a rhizobial E3 ubiquitin ligase [PDF]

, 2018
Chang-Chao Xu, Di Zhang, Dagmar R. Hann, Zhi‐Ping Xie, Christian Staehelin   +4 more
openalex   +1 more source

Inhibition of Protein Disulfide Isomerase (PDIA1) Leads to Proteasome-Mediated Degradation of Ubiquitin-like PHD and RING Finger Domain-Containing Protein 1 (UHRF1) and Increased Sensitivity of Glioblastoma Cells to Topoisomerase II Inhibitors

, 2022
Rima Mouawad, Nouri Neamati
openalex   +2 more sources

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source