Results 131 to 140 of about 33,702 (335)
Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent [PDF]
, 1989 Yael Rosenberg‐Hasson +3 more
openalex +1 more source
Advanced Science, EarlyView.The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li +13 more
wiley +1 more source
Dissecting Ubiquitin Folding Using the Self-Organized Polymer Model [PDF]
arXiv, 2015 Folding of Ubiquitin (Ub) is investigated at low and neutral pH at different temperatures using simulations of the coarse-grained Self-Organized-Polymer model with side chains. The calculated radius of gyration, showing dramatic variations with pH, is in excellent agreement with scattering experiments. At $T_m$ Ub folds in a two-state manner at low and
arxiv
Advanced Science, EarlyView.Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang +10 more
wiley +1 more source
QnAs with Michael L. Dustin. [PDF]
Proc Natl Acad Sci U S A, 2023 Ravindran S.
europepmc +1 more source
Optimal experimental design in an EGFR signaling and down-regulation model [PDF]
arXiv, 2006 We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho ...
arxiv
Different mechanisms that promote protein monoubiquitination [PDF]
, 2015 Protein monoubiquitination is a post-translational modificationthat consists of the conjugation of a single ubiquitin molecule to a target protein residue.
Crosas, Bernat, Puig-Sàrries, Pilar
core
Advanced Science, EarlyView.In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han +10 more
wiley +1 more source
Proteolysis of mitochondria in reticulocytes during maturation is ubiquitin‐dependent and is accompanied by a high rate of ATP hydrolysis [PDF]
, 1985 S. Rapoport +2 more
openalex +1 more source
Characterization of Ubiquitination Site of Inducible cAMP Early Repressor [PDF]
, 2015 Inducible cAMP Early Repressor (ICER) is a negative transcriptional regulator found in eukaryotic cells. ICER has a tumor suppressive activity and is absent in several human cancers. Cancer cells get rid of ICER by a post-translational modification known
Woldeamanuel, Fanaye
core +1 more source