Results 141 to 150 of about 33,702 (335)
Advanced Science, EarlyView.TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang +8 more
wiley +1 more source
The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48. [PDF]
Mol Cell, 2023 Williams C +3 more
europepmc +1 more source
Microinjection of ubiquitin: intracellular distribution and metabolism in HeLa cells maintained under normal physiological conditions. [PDF]
, 1987 Noel G. Carlson, Martin Rechsteiner
openalex +1 more source
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury
Advanced Science, EarlyView.Mitophagy switching drives high‐glucose‐induced vascular endothelial injury. Short‐term high‐glucose exposure upregulates Fis1 expression and enhances Fis1‐TBC1D15 interaction, activating Parkin‐mediated mitophagy. Long‐term high‐glucose exposure reduces Fis1 expression, inhibiting Parkin‐mediated mitophagy and triggering mitophagy switching from ...
Anqi Luo +10 more
wiley +1 more source
Human ubiquitin genes: One member of the UbB gene subfamily is a tetrameric non‐processed pseudogene [PDF]
, 1988 Jack B. Cowland, Ove Wiborg, Jens Vuust
openalex +1 more source
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
Advanced Science, EarlyView.MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi +9 more
wiley +1 more source
Advanced Science, EarlyView.Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian +16 more
wiley +1 more source
Aggregate, Volume 3, Issue 6, December 2022., 2022 Investigation of how the AIE molecules and functionalized AIE nanoparticle impact protein stability, protein homeostasis in cells, biodistribution, and biocompatibility in animal model. Abstract Aggregation‐induced emission (AIE) materials offer promising perspectives in disease diagnosis and therapeutics given their unique optical and photochemical ...
Wang Wan +12 more
wiley +1 more source