Results 141 to 150 of about 117,949 (359)
Advanced Science, EarlyView.During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang +8 more
wiley +1 more source
Human ubiquitin genes: One member of the UbB gene subfamily is a tetrameric non‐processed pseudogene [PDF]
, 1988 Jack B. Cowland, Ove Wiborg, Jens Vuust
openalex +1 more source
Advanced Science, EarlyView.Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source
The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48. [PDF]
Mol Cell, 2023 Williams C +3 more
europepmc +1 more source
Advanced Science, EarlyView.The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao +9 more
wiley +1 more source
New ubiquitin mRNA expressed during chicken spermiogenesis [PDF]
, 1987 Jovita Mezquita +2 more
openalex +1 more source