Results 141 to 150 of about 117,989 (312)

The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity.

Human Molecular Genetics, 2003
Barrington G. Burnett, Fusheng Li, R. Pittman   +2 more
semanticscholar   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

E3 ubiquitin-protein ligase (mouse double minute 2; Mdm2) protein expression is strongly associated with poor overall survival in malignant pleural mesothelioma.

, 2013
Fabian Mairinger, Saskia Ting, Claudia Vollbrecht, Robert Walter, Jens Kollmeier, Sergej Grief, Thomas Hager, Thomas Mairinger, Daniel C. Christoph, Kurt Werner Schmid, Jeremias Wohlschlaeger   +10 more
openalex   +1 more source

The Ubiquitin Switch in Plant Stress Response [PDF]

, 2021
Paymon Doroodian, Zhihua Hua
openalex   +1 more source

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2

Advanced Science, EarlyView.
Domestication of Tartary buckwheat is selected for a salt tolerance mechanism involving the magnesium transporter FtMGT2. Its expression is controlled by the FtAGL16‐FtMYB15L module, which is stabilized under salt stress through a competitive interaction that blocks its degradation by the E3 ligase FtBRG1, ultimately boosting Na⁺ efflux and plant ...
Xiang Lu, Yuqi He, Wenfeng Weng, Zebin Liu, Yuanfen Gao, Yaliang Shi, Wei Li, Dili Lai, Mengyu Zhao, Rintu Jha, Hui Zhao, Guangsheng Li, Chaonan Guan, Shuai Shao, Jingjun Ruan, Sun Hee Woo, Yinan Ouyang, Muriel Quinet, Milen I. Georgiev, Alisdair R. Fernie, Congcong Hou, Kaixuan Zhang, Xu Liu, Meiliang Zhou   +23 more
wiley   +1 more source

Poly-ubiquitylated transmembrane proteins outcompete other cargo for limited space inside clathrin-coated vesicles. [PDF]

Cell Rep
Liu HY, Sarkar S, Yuan F, Ashby G, Hayden CC, Huibregtse JM, Stachowiak JC.   +6 more
europepmc   +1 more source

178 E6AP Ubiquitin Ligase Regulates PML-induced Senescence in Myc-driven Lymphomagenesis

, 2012
Kamil Wolyniec, Jake Shortt, Stephen Opat, RW Johnstone, C.L. Scott, Simon Fox, Andreas Strasser, Sue Haupt, Ygal Haupt   +8 more
openalex   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

A Stable Bioisostere of Ester-Linked Ubiquitin Chains Enables Decoding of Protein Interactors. [PDF]

Chembiochem
Taguchi Y, Tomita T, Nishizawa T, Nakamura D, Saha S, Oyoshi T, Sato K, Mase N, Saeki Y, Narumi T.   +9 more
europepmc   +1 more source

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF‐κB regulation

EMBO Journal, 2012
F. Tokunaga, H. Nishimasu, R. Ishitani, E. Goto, T. Noguchi, K. Mio, Kiyoko Kamei, A. Ma, K. Iwai, O. Nureki   +9 more
semanticscholar   +1 more source