Results 191 to 200 of about 4,901 (243)

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

DOO: integrated multi-omics resources for deep ocean organisms. [PDF]

Nucleic Acids Res
She J, Qian PY, Wu L.
europepmc   +1 more source

SUMOylation of EphB4 enhances its stability in prostate cancer. [PDF]

Br J Cancer
Maharaj MSN, Mertens-Walker I, Lisle JE, Herington A, Stephens C, Chai M, Meutermans W, Stephenson SA.   +7 more
europepmc   +1 more source

ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation. [PDF]

Gut
Yuan Y, Li J, Rao D, Lu X, Chen M, Chen X, Long X, Zhang B, Liang H, Chen Q, Zhao J.   +10 more
europepmc   +1 more source

The structural basis for deubiquitination by the fingerless USP-type effector TssM. [PDF]

Life Sci Alliance
Hermanns T, Uthoff M, Baumann U, Hofmann K.   +3 more
europepmc   +1 more source

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The measurement of ubiquitin and ubiquitinated proteins

Electrophoresis, 1999
Ubiquitination of key cellular proteins involved in signal transduction, gene transcription and cell-cycle regulation usually condemns those proteins to proteasomal or lysosomal degradation. Additionally, cycles of reversible ubiquitination regulate the function of certain proteins in a manner analogous to phosphorylation.
E G, Mimnaugh, P, Bonvini, L, Neckers
openaire   +2 more sources

Ubiquitin and ubiquitin conjugates in human lens

Experimental Eye Research, 1992
Ubiquitin, an 8.5 kDa polypeptide found almost universally in plants and animals, is a normal component in the lens. The best documented function for ubiquitin involves its conjugation to proteins as a signal to initiate degradation. Conjugates for ubiquitin-dependent degradation tend to be of very high molecular mass and are rapidly degraded.
J, Jahngen-Hodge, D, Cyr, E, Laxman, A, Taylor   +3 more
openaire   +2 more sources

One Ubiquitin, Two Ubiquitin, Three Ubiquitin, Four

Science, 2007
The role of protein ubiquitination is well known in promoting regulated protein degradation. Mukhopadhyay and Riezman review what is known about the contribution of protein ubiquitination in other cellular pathways, including intracellular signaling, endocytosis, and protein sorting. D. Mukhopadhyay, H.
openaire   +2 more sources

Activation of Ubiquitin and Ubiquitin-Like Proteins

2010
Attachment of ubiquitin and ubiquitin-like proteins to cellular targets represents a fundamental regulatory strategy within eukaryotes and exhibits remarkably pleiotropic effects on cell function. These posttranslational modifications share a common mechanism comprised of three steps: an activating enzyme to couple ATP hydrolysis to formation of a high-
Frederick C, Streich, Arthur L, Haas
openaire   +2 more sources