Results 221 to 230 of about 33,702 (335)

Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system [PDF]

, 1994
Dganit Shkedy, Hedva Gonen, Beatrice Bercovich, Aaron Ciechanover   +3 more
openalex   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Elucidation of Ubiquitin-Related Functions via an Ubiquitin Overexpression Approach. [PDF]

Cells
Masuda R, Yoshikawa M, Moriuchi R, Oba Y, Dohra H, Kimura Y.   +5 more
europepmc   +1 more source

Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells

, 1992
Liu
openalex   +2 more sources

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold [PDF]

, 2020
Deegan, Tom D., Fujisawa, Ryo, Labib, Karim P. M., Mukherjee, Progya P., Polo Rivera, Cristian   +4 more
core   +3 more sources

SUMOylation of SETD8 Promotes Tumor Growth by Methylating and Stabilizing MYC in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer (BC), MYC serves as a novel substrate of SETD8 to be methylated at lysine 412, which enhances MYC protein stability by preventing the CHIP‐mediated degradation and ultimately promotes tumor growth. SUMOylation of SETD8 leads to SETD8 stabilization and enhances MYC methylation.
Xia Zhang, Zhenxuan Chen, Xiaobo He, Jingxuan Wang, Jianliang Zhong, Yezi Zou, Xianchong Zheng, Yujie Lin, Ruhua Zhang, Tiebang Kang, Liwen Zhou, Yuanzhong Wu   +11 more
wiley   +1 more source

Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. [PDF]

Nat Struct Mol Biol
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G.   +10 more
europepmc   +1 more source

Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43. [PDF]

Cells, 2022
Zhang Q, Terawaki S, Oikawa D, Okina Y, Usuki Y, Ito H, Tokunaga F.   +6 more
europepmc   +1 more source

Conjugation of Ubiquitin to Proteins from Green Plant Tissues [PDF]

, 1991
Bjarke Veierskov, Ian B. Ferguson
openalex   +1 more source

The SlDOF9‐SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato

Advanced Science, EarlyView.
Root‐knot nematode (RKN) disease seriously affects the yield and quality of vegetable crops. SlDOF9‐SlSWEET17 model helps plants resist RKN infection during early stage by switching off the sugar transport capacity of other SlSWEET proteins that are hijacked by RKNs.
Xiaoyun Wang, Zhimei Wang, Xinyue Tang, Jiamei Qin, Xiaoxuan Zhou, Lixia Gu, Huihui Bian, Lulu Sun, Huang Huang, Rui Yang, Jianli Wang, Shaohui Wang, Shuangchen Chen, Zhongren Yang, Wenchao Zhao   +14 more
wiley   +1 more source