Results 231 to 240 of about 117,949 (359)

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

, 1991
Avram Hershko, D Ganoth, John R. Pehrson, Robert E. Palazzo, Lucie Cohen   +4 more
openalex   +1 more source

Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43. [PDF]

Cells, 2022
Zhang Q, Terawaki S, Oikawa D, Okina Y, Usuki Y, Ito H, Tokunaga F.   +6 more
europepmc   +1 more source

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators

Advanced Science, EarlyView.
A computational approach to identify and characterize ligandable binding pockets on E3 ligases is presented. As a validation case, the first low‐micromolar small moleculesthat bind to the FBW7 E3 ligase are identified and confirmed to bind at the intended site.
Míriam Martínez‐Cartró, Álvaro Serrano‐Morrás, Andrea Bertran‐Mostazo, Roger Castaño‐Muñiz, Salvatore Scaffidi, Varbina Ivanova, Noémi Csorba, József Simon, Péter Ábrányi‐Balogh, Yunfeng Li, György M. Keserü, Bing Hao, Xavier Barril, Carles Galdeano   +13 more
wiley   +1 more source

Formation of a stable adduct between ubiquitin and the Arabidopsis ubiquitin-conjugating enzyme, AtUBC1+.

, 1993
Michael L. Sullivan, Richard D. Vierstra
openalex   +1 more source

The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase [PDF]

, 1990
Ian N.M. Day, L J Hinks, Richard J. Thompson   +2 more
openalex   +1 more source

Proteomic techniques to probe the ubiquitin landscape

Proteomics, 2016
P. Beaudette, O. Popp, G. Dittmar
semanticscholar   +1 more source

Cloning, bioinformatics analysis, and expression of the ubiquitin 2 (ubq-2) gene from the dog roundworm <i>Toxocara canis</i>. [PDF]

Front Vet Sci
Zhu P, Hu X, Huang J, Wang L, Wang Z, Wang R, Fan X, Wei G, He Q, Li Z, Zhou X, Wang H, Xie Y.   +12 more
europepmc   +1 more source

The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin. [PDF]

J Biol Chem, 2022
Lombardi PM, Haile S, Rusanov T, Rodell R, Anoh R, Baer JG, Burke KA, Gray LN, Hacker AR, Kebreau KR, Ngandu CK, Orland HA, Osei-Asante E, Schmelyun DP, Shorb DE, Syed SH, Veilleux JM, Majumdar A, Mosammaparast N, Wolberger C.   +19 more
europepmc   +1 more source

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source

Heterogeneity in the structure of the ubiquitin conjugates of human alpha globin.

, 1994
Joseph R. Shaeffer
openalex   +1 more source