Results 231 to 240 of about 33,989 (317)

‘ER degradation’ of a mutant yeast plasma membrane protein by the ubiquitin‐proteasome pathway [PDF]

, 1998
Jean‐Marc Galan, B. Cantegrit, Catherine Garnier, Olivier Namy, Rosine Haguenauer‐Tsapis   +4 more
openalex   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Identification of aberrant interferon-stimulated gene associated host responses potentially linked to poor prognosis in COVID-19 during the Omicron wave. [PDF]

Virol J
Li Z, Peng M, Cheng L, Wang Z, Wu Z, Feng F, Feng X, Wang S, Guo Y, Li Y.   +9 more
europepmc   +1 more source

There's the Rub: a novel ubiquitin-like modification linked to cell cycle regulation [PDF]

, 1998
Mark Hochstrasser
openalex   +1 more source

MPSR1 is a cytoplasmic PQC E3 ligase for eliminating emergent misfolded proteins in Arabidopsis thaliana [PDF]

, 2017
Cho, Seok Keun, Kim, Jong Hum, Kim, Woo Taek, Oh, Tae Rin, Ryu, Moon Young, Yang, Seong Wook   +5 more
core   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Impaired K48-polyubiquitination downmodulates mouse norovirus propagation. [PDF]

Front Cell Infect Microbiol
Wakeford E, Werkmeister E, Cayet D, Poiret S, Daniel C, Mackenzie J, Sirard JC, Lafont F, Muharram G.   +8 more
europepmc   +1 more source

Functional and physical characterization of the cell cycle ubiquitin-conjugating enzyme CDC34 (UBC3). Identification of a functional determinant within the tail that facilitates CDC34 self-association

, 1994
Christopher P. Ptak, John A. Prendergast, Robert Hodgins, C.M. Kay, Vincent Chau, Michael J. Ellison   +5 more
openalex   +1 more source

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation

Advanced Science, EarlyView.
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim, Gyeongseok Yang, Chaelyeong Lim, Gaeun Park, Jaemo Lee, Youjung Sim, Ja‐Hyoung Ryu   +6 more
wiley   +1 more source

Insights into the fungal secretomes and their roles in the formation and stabilization of the biogenic silver nanoparticles. [PDF]

RSC Adv
Santana da Costa T, Delgado GG, Braga CB, Tasic L.   +3 more
europepmc   +1 more source