Results 231 to 240 of about 33,989 (317)
‘ER degradation’ of a mutant yeast plasma membrane protein by the ubiquitin‐proteasome pathway [PDF]
Jean‐Marc Galan+4 more
openalex +1 more source
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma+9 more
wiley +1 more source
Identification of aberrant interferon-stimulated gene associated host responses potentially linked to poor prognosis in COVID-19 during the Omicron wave. [PDF]
Li Z+9 more
europepmc +1 more source
There's the Rub: a novel ubiquitin-like modification linked to cell cycle regulation [PDF]
Mark Hochstrasser
openalex +1 more source
MPSR1 is a cytoplasmic PQC E3 ligase for eliminating emergent misfolded proteins in Arabidopsis thaliana [PDF]
Cho, Seok Keun+5 more
core +1 more source
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen+9 more
wiley +1 more source
Impaired K48-polyubiquitination downmodulates mouse norovirus propagation. [PDF]
Wakeford E+8 more
europepmc +1 more source
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim+6 more
wiley +1 more source
Insights into the fungal secretomes and their roles in the formation and stabilization of the biogenic silver nanoparticles. [PDF]
Santana da Costa T+3 more
europepmc +1 more source