Results 241 to 250 of about 33,989 (317)
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang+13 more
wiley +1 more source
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu+20 more
wiley +1 more source
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong+9 more
wiley +1 more source
p.Phe508del-CFTR Trafficking: A Protein Quality Control Perspective Through UPR, UPS, and Autophagy. [PDF]
Trouvé P, Férec C.
europepmc +1 more source
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li+15 more
wiley +1 more source
The structural basis for deubiquitination by the fingerless USP-type effector TssM. [PDF]
Hermanns T+3 more
europepmc +1 more source
USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang+9 more
wiley +1 more source
Structural basis for the ubiquitin chain recognition of the human 26S proteasome
Amann SJ+9 more
europepmc +1 more source