Results 261 to 270 of about 117,989 (312)

Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo

Juan A. Garcia-Sanchez, Elodie Bonnet, Céline Loubatier, Anne Doye, Guillaume Paillier, Fabien Segui, Frédéric Larbret, Paul Chaintreuil, Ludovic Batistic, Cédric Torre, Marcel Deckert, Jolanta Polanowska, Patrick Munro, Laurent Boyer, Orane Visvikis   +14 more
openalex   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

ISG15 modulates inflammatory profiles and ability to activate CD8 + T cells in bone marrow-derived dendritic cells. [PDF]

Cell Mol Life Sci
Martínez-Fleta P, Pertusa C, Fernández-Delgado I, Izquierdo-Serrano R, Ramírez-Huesca M, Fernández-Gallego N, Calzada-Fraile D, Moya-Ruiz E, Castillo-González R, Guerra S, Martín-Gayo E, Sánchez-Madrid F.   +11 more
europepmc   +1 more source

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

Elucidation of Ubiquitin-Related Functions via an Ubiquitin Overexpression Approach. [PDF]

Cells
Masuda R, Yoshikawa M, Moriuchi R, Oba Y, Dohra H, Kimura Y.   +5 more
europepmc   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10. [PDF]

J Cell Sci
Roberts JE, Huynh PT, Carale LO, Whiteley AM.   +3 more
europepmc   +1 more source

α-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies. [PDF]

Front Mol Neurosci
Ho HH, Wing SS.
europepmc   +1 more source

Ubiquitin and Ubiquitin-Like Modifications in Organelle Stress Signaling: Ub, Ub, Ub, Ub, Stayin' Alive, Stayin' Alive. [PDF]

Bioessays
Lafont E, Chevet E.
europepmc   +1 more source

The Multifaceted Ubiquitination of BIK1 During Plant Immunity in Arabidopsis thaliana. [PDF]

Int J Mol Sci
Fu J, Wang H, Chen Y, Zhang C, Zou Y.
europepmc   +1 more source