Results 261 to 270 of about 117,949 (359)

Dephosphorylation Targets Bcl-2 for Ubiquitin-dependent Degradation: A Link between the Apoptosome and the Proteasome Pathway [PDF]

, 1999
Stefanie Dimmeler, Kristin Breitschopf, Judith Haendeler, Andreas M. Zeiher   +3 more
openalex   +1 more source

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

Advanced Science, EarlyView.
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai, Tianxing Pang, Shiyu Peng, Shenshen Zou, Zhiping Deng, Nobuhiro Suzuki, Zhensheng Kang, Ida Bagus Andika, Liying Sun   +8 more
wiley   +1 more source

The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.

Proceedings of the National Academy of Sciences of the United States of America, 2005
Barrington G. Burnett, R. Pittman
semanticscholar   +1 more source

NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA

Advanced Science, EarlyView.
MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen, Ying Liang, Hongyan Wei, Mengxing Liu, Jin Wu, Wei Li, Wenxuan Li, Yuxiao Jin, Yinshan Li, Wei Zhao, Min Xiao, Kaicheng Zhou, Shuai Yang, Wenqiang Yu   +13 more
wiley   +1 more source

A Simple, Quick, and Scalable Route to Fluorogenic Ubiquitin and Ubiquitin-Like Protein Substrates for Assessing Activities of Deubiquitinases and Ubiquitin-Like Protein-Specific Proteases. [PDF]

ACS Chem Biol
Chanda S, Pham A, Shi Y, Atla S, Liu WR.
europepmc   +1 more source

PD‐L1‐Targeting Biomimetic Photoresponsive Thermosensitive Liposomes for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Tan et al. developed a platelet membrane‐coated, thermoresponsive liposome for targeted, light‐controlled delivery of fluorinated peptides that promotes programmed death‐ligand 1 degradation, induces tumor immunogenic cell death, suppresses solid tumors and metastases, and triggers durable immune memory, offering a promising strategy for peptide‐based ...
Manman Tan, Chengyu Shi, Guangyi Chi, Xinwan Su, Fangzhou Liu, Linyu Zhu, Guangqian Cheng, Xiangyi Chen, Meng Yu, Yijian Chen, Ying Wang, Yu Chen, ShuLing Yan, Wenfei Wu, Qingfeng Yan, Jianzhong Shao, Kai Wang, Xiangrui Liu, Min Zhou, Aifu Lin   +19 more
wiley   +1 more source

A human ubiquitin carboxyl extension protein functions in yeast.

, 1990
Brett P. Monia, David J. Ecker, Daniel Finley, Stanley T. Crooke   +3 more
openalex   +1 more source

Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo

EMBO Reports, 2014
H. Vlaming, T. Welsem, E. L. Graaf, David Ontoso, A. Altelaar, Pedro A. San-Segundo, A. Heck, F. Leeuwen   +7 more
semanticscholar   +1 more source

Identification of aberrant interferon-stimulated gene associated host responses potentially linked to poor prognosis in COVID-19 during the Omicron wave. [PDF]

Virol J
Li Z, Peng M, Cheng L, Wang Z, Wu Z, Feng F, Feng X, Wang S, Guo Y, Li Y.   +9 more
europepmc   +1 more source

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source