Results 281 to 290 of about 33,702 (335)

Ubiquitin-Dependent Signaling: The Role of Ubiquitination in the Response of Cells to Their Environment.

, 1999
Keith D. Wilkinson
openalex   +1 more source

TRIB3 suppresses milk fatty acids metabolism by inhibiting p‐AKT/PPARG signaling in goat mammary epithelial cells

Animal Research and One Health, EarlyView.
In this study, it revealed that TRIB3 could mediate the transcriptional activity of PPARG, inhibit the phosphorylation of akt, and reduce the expression of lipid metabolism‐related genes, thus inhibiting TAG synthesis and affecting fatty acid composition.
Xinglong Gong, Tan Pan, Tiantian Xiong, Yifan Zhu, Juan J. Loor, Chengming Han, Yifan Li, Huan Lei, Jun Luo, Cong Li   +9 more
wiley   +1 more source

Arylamines QSAR-Based Design and Molecular Dynamics of New Phenylthiophene and Benzimidazole Derivatives with Affinity for the C111, Y268, and H73 Sites of SARS-CoV-2 PLpro Enzyme. [PDF]

Pharmaceuticals (Basel)
Sabadini G, Mellado M, Morales C, Mella J.   +3 more
europepmc   +1 more source

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc

, 1999
S. E. Salghetti
openalex   +2 more sources

Expert Perspectives on a Clinical Challenge: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, Accepted Article.
Systemic vasculitis describes a collection of rare diseases each caused by inflammation of blood vessel walls that can cause severe systemic complications [[3, 4]](#ref‐0003). The pattern of vascular inflammation and resultant damage is frequently variable and may be mimicked, or directly triggered, by infection or malignancy.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

m6A‐mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly

Autism Research, EarlyView.
ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD‐DM) seen at three years of age is associated with co‐occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD‐DM have yet to be delineated. In this study, we identified additional ASD‐DM candidate genes
Sierra S. Nishizaki, Nicholas K. Haghani, Gabriana N. La, Natasha Ann F. Mariano, José M. Uribe‐Salazar, Gulhan Kaya, Melissa Regester, Derek Sayre Andrews, Christine Wu Nordahl, David G. Amaral, Megan Y. Dennis   +10 more
wiley   +1 more source

Sortase mediated protein ubiquitination with defined chain length and topology. [PDF]

RSC Chem Biol
Raniszewski NR, Beyer JN, Noel MI, Burslem GM.   +3 more
europepmc   +1 more source

Coral Restoration in the Omics Era: Development of Point‐of‐Care Tools for Monitoring Disease, Reproduction, and Thermal Stress

BioEssays, EarlyView.
Shown are different multi‐omics approaches that are used to identify potential biomarkers of coral health and disease. The integration of these data streams, using cutting‐edge molecular diagnostic technologies, including colorimetric dipsticks, lateral flow assays, and colorimetric LAMP (loop‐mediated isothermal amplification), holds the promise to ...
Erin E. Chille, Timothy G. Stephens, Shrinivas Nandi, Haoyu Jiang, Michael J. Gerdes, Olivia M. Williamson, Alexander Neufeld, Phanor Montoya‐Maya, Debashish Bhattacharya   +8 more
wiley   +1 more source

Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes. [PDF]

Int J Mol Sci
Delrue C, Dendooven A, Vandendriessche A, Speeckaert R, De Bruyne S, Speeckaert MM.   +5 more
europepmc   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source