Results 281 to 290 of about 33,989 (317)

SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3. [PDF]

Cell Biol Toxicol
Bu J, Xu X, Luo Y, Liu J, Zhou F.
europepmc   +1 more source

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

Aggregate, EarlyView.
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko, Anna I. Sulatskaya   +3 more
wiley   +1 more source

Sortase mediated protein ubiquitination with defined chain length and topology. [PDF]

RSC Chem Biol
Raniszewski NR, Beyer JN, Noel MI, Burslem GM.   +3 more
europepmc   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Expanding the SIAH1‐Associated Phenotypic Spectrum: Insights From Loss‐of‐Function Variants

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SIAH1 encodes for a RING‐type E3 ubiquitin ligase involved in protein ubiquitination. More specifically, it positively regulates Wnt signaling through promoting the accumulation of β‐catenin and mediates ubiquitination and degradation of Akt3 in neural development.
Liza Douiev, Paula Fernandez Alvarez, Marika Frank, Lucy Hanington, Trevor L. Hoffman, Mira B. Irons, Jenny Kim, Akash Kumar, Amaia Lasa‐Aranzasti, Diana Le Duc, Helen Livesey, Oliver Murch, Deborah Shears, Brandon K. Walther, Tamar Harel   +14 more
wiley   +1 more source

Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes. [PDF]

Int J Mol Sci
Delrue C, Dendooven A, Vandendriessche A, Speeckaert R, De Bruyne S, Speeckaert MM.   +5 more
europepmc   +1 more source

Post-Translational Variants of Major Proteins in Amyotrophic Lateral Sclerosis Provide New Insights into the Pathophysiology of the Disease. [PDF]

Int J Mol Sci
Bedja-Iacona L, Richard E, Marouillat S, Brulard C, Alouane T, Beltran S, Andres CR, Blasco H, Corcia P, Veyrat-Durebex C, Vourc'h P.   +10 more
europepmc   +1 more source

Toxicological Responses of Juvenile Gilthead Seabream to Enniatin B and Fumonisin B1. [PDF]

Int J Mol Sci
Mello FV, Pereira C, Özkan B, Maulvault AL, Soares F, Pousão-Ferreira P, Fernandes JO, Cunha SC, Marques A, Anacleto P.   +9 more
europepmc   +1 more source

Adaptable Alchemy: Exploring the Flexibility of Specialized Metabolites to Environmental Perturbations Through Post-Translational Modifications (PTMs). [PDF]

Plants (Basel)
Cimmino L, Staiti A, Carputo D, Docimo T, D'Amelia V, Aversano R.   +5 more
europepmc   +1 more source

Transcriptomic analysis of differential expression between surviving and nonsurviving patients infected by the SARS-CoV-2 Delta variant. [PDF]

Sci Rep
Ivan V, Tatiana U, Alexandra P, Mikhail N, Artem I, Valeriia P, Elena G, Irina S, Valentina M, Maria S, Yurii P, Sofya P, Petr S.   +12 more
europepmc   +1 more source