Results 31 to 40 of about 33,702 (335)
Mechanical unfolding and refolding pathways of ubiquitin [PDF]
Phys. Rev. Lett. 100, 158104 (2008), 2008 Mechanical unfolding and refolding of ubiquitin are studied by Monte Carlo simulations of a Go model with binary variables. The exponential dependence of the time constants on the force is verified, and folding and unfolding lengths are computed, with good agreement with experimental results. Furthermore, the model exhibits intermediate kinetic states,
arxiv +1 more source
Developmental and tissue specific changes of ubiquitin forms in Drosophila melanogaster. [PDF]
, 2018 In most Eukaryotes, ubiquitin either exists as free monoubiquitin or as a molecule that is covalently linked to other proteins. These two forms cycle between each other and due to the concerted antagonistic activity of ubiquitylating and deubiquitylating
Deák, Péter +4 more
core +2 more sources
Molecular Plant-Microbe Interactions, 2009 Plant responses against pathogens cause up- and downward shifts in gene expression. To identify differentially expressed genes in a plant-virus interaction, susceptible tomato plants were inoculated with the potyvirus Pepper yellow mosaic virus (PepYMV ...
Poliane Alfenas-Zerbini +5 more
doaj +1 more source
Regulation of endoplasmic reticulum-associated protein degradation (ERAD) by ubiquitin [PDF]
, 2014 Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-mediated assistance in folding and the selective targeting of terminally misfolded species to a pathway called ER-associated protein degradation, or simply ERAD.
Goder, Veit, Lemus Rodríguez,Leticia
core +2 more sources
Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains
Cell Reports, 2016 Myosin VI is critical for cargo trafficking and sorting during early endocytosis and autophagosome maturation, and abnormalities in these processes are linked to cancers, neurodegeneration, deafness, and hypertropic cardiomyopathy.
Fahu He +9 more
doaj +1 more source
Refolding upon force quench and pathways of mechanical and thermal unfolding of ubiquitin [PDF]
Biophysical Journal, 92, 547-561 (2007), 2006 The refolding from stretched initial conformations of ubiquitin (PDB ID: 1ubq) under the quenched force is studied using the Go model and the Langevin dynamics. It is shown that the refolding decouples the collapse and folding kinetics. The force quench refolding times scale as tau_F ~ exp(f_q*x_F/k_B*T), where f_q is the quench force and x_F = 0.96 nm
arxiv +1 more source
The CaVβ Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination. [PDF]
, 2016 CaVβ subunits interact with the voltage-gated calcium channel CaV2.2 on a site in the intracellular loop between domains I and II (the I-II loop). This interaction influences the biophysical properties of the channel and leads to an increase in its ...
Dolphin, AC, Page, KM, Rothwell, SW
core +1 more source
Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]
Biochemistry, 2011 Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Rachel E. Klevit +4 more
openaire +3 more sources
Experimental and Molecular Medicine, 2018 Experimental & molecular medicine Researchers may have found a new target for treatment of multiple myeloma (MM), a common type of blood cancer.
Lili Zhou +7 more
doaj +1 more source
Frontiers in Physiology, 2018 Structural and functional alterations of mitochondria are intimately linked to a wide array of medical conditions. Many factors are involved in the regulation of mitochondrial function, including cytokines, chaperones, chemokines, neurosteroids, and ...
Victoria O. Polyakova +10 more
doaj +1 more source