Results 121 to 130 of about 65,761 (163)

Emerging tools in plant genome editing. [PDF]

Front Genome Ed
Sharma S, Saroha NK, Sehrawat A, Tang G, Singh D, Teotia S.   +5 more
europepmc   +1 more source

Nitrene-transfer from azides to isocyanides: Unveiling its versatility as a promising building block for the synthesis of bioactive heterocycles. [PDF]

iScience
Sawant DM, Joshi G, Ansari AJ.
europepmc   +1 more source

Nanomaterial Adjuvants for Veterinary Vaccines: Mechanisms and Applications. [PDF]

Research (Wash D C)
He L, Pan R, Liang R, Li B, Zhang P, He S, Li B, Li Y.   +7 more
europepmc   +1 more source

Recent Developments in Functional Polymers via the Kabachnik-Fields Reaction: The State of the Art. [PDF]

Molecules
Yuan R, He X, Zhu C, Tao L.
europepmc   +1 more source

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Ugi reaction-assisted assembly of covalent PROTACs against glutathione peroxidase 4.

Bioorganic chemistry (Print), 2023
Inducing cell ferroptosis by inactivating glutathione peroxidase 4 (GPX4) is a popular cancer treatment strategy. However, only few GPX4 inhibitors have been developed to date. PROteolysis Targeting Chimera (PROTAC) is a promising approach to provide new
Liquan Zhu, Shiqi Hu, Xiaoqiao Yan, Qian Zeng, Bei Zhang, Linye Jiang, S. Yao, Jingyan Ge   +7 more
semanticscholar   +1 more source

Synthesis of 4-Tetrazolyl-Substituted 3,4-Dihydroquinazoline Derivatives with Anticancer Activity via a One-Pot Sequential Ugi-Azide/Palladium-Catalyzed Azide-Isocyanide Cross-Coupling/Cyclization Reaction.

Journal of Organic Chemistry, 2022
A new one-pot preparation of 4-tetrazolyl-3,4-dihydroquinazolines has been reported. The Ugi-azide reactions of 2-azidobenzaldehydes, amines, trimethylsilyl azide, and isocyanides produced azide intermediates without separation, which were treated with ...
Jun Xiong, Hui-Ting He, He-Yu Yang, Zhi-Gang Zeng, Cheng-Ran Zhong, Hang Shi, Meng-Ling Ouyang, Yuan-Yuan Tao, Yong-Long Pang, Yang-Hong Zhang, Bo Hu, Zi-Xiang Fu, Xiao-Lei Miao, Haili Zhu, Gang Yao   +14 more
semanticscholar   +1 more source

Ugi cascade sequence for the construction of 3-pyrrolin-2-one scaffolds: anti-proliferation in prostate cancer cells.

Chemistry - An Asian Journal, 2022
Herein, a small series of 3-pyrrolin-2-ones was efficiently synthesized through a three-step Ugi cascade sequence. This method features readily available substrates, simple aqueous workup procedures and good yields, dramatically improving generality of ...
J. Lei, Dong-lin Yang, J. Xu, J. Li, Ge Zhang, Xu Xiong, Zhigang Xu, Zhong-Zhu Chen   +7 more
semanticscholar   +1 more source

Synthesis of indoline-piperidinonesviaa novel Ugi, ring expansion,pseudo-Dieckmann condensation and rearrangement cascade reaction

, 2020
An Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction was discovered for the synthesis of indoline-piperidinones in one pot. A series of targeted compounds was prepared by means of a mild reaction and a simple operation
J. Lei, Gui-ting Song, Yafei Luo, D. Tang, Wei Yan, Hong‐yu Li, Zhong-Zhu Chen, Zhigang Xu   +7 more
semanticscholar   +1 more source

Facile Construction of Hydantoin Scaffolds via a Post-Ugi Cascade Reaction

Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry, 2018
A small series of hydantoins was efficiently synthesized via a two-step Ugi/cyclization reaction sequence using alkyne group as a leaving group under basic conditions.
Zhigang Xu, Yong Ding, J. Meng, D. Tang, Yong Li, J. Lei, Chuan Xu, Zhong-Zhu Chen   +7 more
semanticscholar   +1 more source