Complexity-Building ESIPT-Assisted Synthesis of Fused Polyheterocyclic Sulfonamides [PDF]
Molecules, 2023 Excited State Intramolecular Proton Transfer (ESIPT), originally discovered and explored in depth in a number of extensive photophysical studies, is more recently rediscovered as a powerful synthetic tool, offering rapid access to complex ...
Srinivas Beduru, Andrei G. Kutateladze
doaj +4 more sources
Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles [PDF]
Journal of the American Chemical Society, 2020 We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I ...
Gang-Wei Wang, Olivia Boyd, Tom A Young
exaly +7 more sources
Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy [PDF]
Molecules, 2023 A diversity-oriented synthesis (DOS) of two new polyheterocyclic compounds was performed via an Ugi-Zhu/cascade (N-acylation/aza Diels-Alder cycloaddition/decarboxylation/dehydration)/click strategy, both step-by-step to optimize all involved ...
Roberto E. Blanco-Carapia +4 more
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Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds [PDF]
SynOpen, 2022 The synthesis of aromatic heterocycles has attracted substantial attention due to the abundance of these heterocycles in drug molecules, natural products, and other compounds of biological interest.
Shabber Mohammed +2 more
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One-Pot Sequence of Staudinger/aza-Wittig/Castagnoli–Cushman Reactions Provides Facile Access to Novel Natural-like Polycyclic Ring Systems [PDF]
Molecules, 2022 Realization of the one-pot Staudinger/aza-Wittig/Castagnoli–Cushman reaction sequence for a series of azido aldehydes and homophthalic anhydrides is described. The reaction proceeded at room temperature and delivered novel polyheterocycles related to the
Rodion Lebedev +4 more
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Free-radical cyclization approach to polyheterocycles containing pyrrole and pyridine rings [PDF]
Beilstein Journal of Organic Chemistry, 2021 A wide range of derivatives with new pyrido[2,1-a]pyrrolo[3,4-c]isoquinoline skeleton was synthesized by free-radical intramolecular cyclization of o-bromophenyl-substituted pyrrolylpyridinium salts using the (TMS)3SiH/AIBN system.
Ivan P. Mosiagin +5 more
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Recent Developments in Azomethine Ylide-Initiated Double Cycloadditions [PDF]
MoleculesAzomethine ylides (AMYs) have a nitrogen–carbon double bond and an electron lone pair on the nitrogen atom. They are essential 1,3-dipoles for [3+2] cycloadditions in the synthesis of pyrrolidine-containing heterocycles.
Tieli Zhou +4 more
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Highly Stereoselective Ugi/Pictet-Spengler Sequence. [PDF]
J Org Chem, 2022 Discovering novel synthetic routes for rigid nitrogen-containing polyheterocycles using sustainable, atom-economical, and efficient (= short) synthetic pathways is of high interest in organic chemistry. Here, we describe an operationally simple and short
Zhang B, Kurpiewska K, Dömling A.
europepmc +4 more sources
An easy access to furan fused polyheterocyclic systems [PDF]
Molecules, 2022 Nitrostilbenes characterized by two different or differently substituted aryl moieties can be obtained from the initial ring-opening of 3-nitrobenzo[b]thiophene with amines.
Alice Benzi +6 more
core +5 more sources
Enantioselective aza-electrophilic dearomatization of naphthalene derivatives [PDF]
Nature CommunicationsThe catalytic asymmetric dearomatization of naphthalenes is a pivotal strategy for generating enantioenriched three-dimensional aliphatic polycycles from flat aromatic precursors.
Jun Liu +5 more
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