Palladium‐Catalyzed Dual Csp2─Csp3 Bond Formation: A Versatile Platform for the Synthesis of Benzo‐Fused Heterocycles [PDF]
Advanced ScienceTransition‐metal‐catalyzed transformations offer a powerful approach to rapidly synthesize complex benzo‐fused heterocycles, crucial for drug and material development.
Jiahui Huang +9 more
doaj +3 more sources
Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols [PDF]
European Journal of Organic ChemistryWe report the efficient, sustainable one-pot synthesis of a wide variety of N-polyheterocycles, such as imidazo-quinolines and quinoxalines, and furoquinolines, from easily available nitroaromatics and glycols via a molybdenum catalytic domino reduction ...
Nuria Cases Vadell +2 more
exaly +4 more sources
Copper-catalyzed modular assembly of polyheterocycles [PDF]
The Journal of Organic Chemistry, 2020 Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper ...
Dömling, Alexander +5 more
core +6 more sources
Synthetic routes to benzimidazole-based fused polyheterocycles [PDF]
ARKIVOC, 2010 The review article represents a survey covering the synthetic strategies leading to benzimidazole- based fused polyheterocyclic systems utilizing simple reactive benzimidazole synthons since 1980. The polyheterocyclic systems are classified based on the number of rings; tetra-, penta-, hexa- and hepta-fused ring systems.
Kamal M. Dawood, Bakr F. Abdel-Wahab
doaj +2 more sources
Diverse Synthesis of Fused Polyheterocyclic Compounds via [3 + 2] Cycloaddition of In Situ-Generated Heteroaromatic N-Ylides and Electron-Deficient Olefins [PDF]
Molecules, 2023 [3 + 2] Cycloaddition reactions of heteroaromatic N-ylides with electron-deficient olefins have been developed. The heteroaromatic N-ylides, in situ generated from N-phenacylbenzothiazolium bromides, can smoothly react with maleimides under very mild ...
Zhen-Hua Wang +7 more
doaj +2 more sources
Methanol as a C1 Source for the Synthesis of 1,3‐Polyheterocyclic Systems
European Journal of Organic Chemistry, 2023 AbstractA very attractive approach toward 1,3‐polyheterocyclic systems was provided exploiting the copper‐catalyzed reaction of aminoalcohols and diaminoalkanes, in oxidative conditions and in the presence of methanol. The synthetic pathway showed the involvement of methanol both as solvent and as a reagent, making the procedure particularly efficient ...
Molteni L. +4 more
openaire +2 more sources
Mo-Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties. [PDF]
Chemistry, 2021 A catalytic domino reduction–imine formation– intramolecular cyclization–oxidation for the general synthesis of a wide variety of biologically relevant N-polyheterocycles, such as quinoxaline- and quinoline-fused derivatives, and phenanthridines, is ...
Hernández-Ruiz R +6 more
europepmc +3 more sources
A Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-Distortion. [PDF]
Front Chem, 2018 In the interdisciplinary research field of chemical biology and drug discovery, diversity-oriented synthesis (DOS) has become indispensable in the construction of novel small-molecule libraries rich in skeletal and stereochemical diversity.
Yi S, Varun BV, Choi Y, Park SB.
europepmc +3 more sources
Complex Polyheterocycles and the Stereochemical Reassignment of Pileamartine A via Aza-Heck Triggered Aryl C–H Functionalization Cascades [PDF]
Journal of the American Chemical Society, 2021 Javier García-Cárceles +2 more
exaly +2 more sources
Molbank, 2023 The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1H-1,2,3 ...
Perla Islas-Jácome +6 more
doaj +1 more source