Results 21 to 30 of about 517 (172)

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils. [PDF]

J Org Chem, 2020
A BF3×OEt2 catalyzed intramolecular Povarov reaction was used to synthesize a library of 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics.
Adolfsson DE, Tyagi M, Singh P, Deuschmann A, Ådén J, Gharibyan AL, Jayaweera SW, Lindgren AEG, Olofsson A, Almqvist F, Almqvist F.   +10 more
europepmc   +2 more sources

Recent Applications of Quinolinium Salts in the Synthesis of Annulated Heterocycles

SynOpen, 2022
Quinoline derivatives are frequently found in natural products and biologically active compounds; however, construction of quinoline fused polyheterocycles is a challenging goal in synthetic organic chemistry.
Suven Das
doaj   +1 more source

Synthesis and Conformational Analysis of Naphthoxazine-Fused Phenanthrene Derivatives

Molecules, 2020
The synthesis of new phenanthr[9,10-e][1,3]oxazines was achieved by the direct coupling of 9-phenanthrol with cyclic imines in the modified aza-Friedel–Crafts reaction followed by the ring closure of the resulting bifunctional aminophenanthrols with ...
Khadija Belasri, Leila Topal, Matthias Heydenreich, Andreas Koch, Erich Kleinpeter, Ferenc Fülöp, István Szatmári   +6 more
doaj   +1 more source

Cp∗Rh/Ag catalyzed C–H activation/cyclization sequences of NH-sulfoximines to fused aza-polyheterocycles under gentle conditions

Green Synthesis and Catalysis, 2023
Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides.
Jiapian Huang, Fei Liu, Feihua Du, Linghui Zeng, Zhiyuan Chen   +4 more
doaj   +1 more source

Diverse Synthesis of Fused Polyheterocyclic Compounds via [3 + 2] Cycloaddition of In Situ-Generated Heteroaromatic N-Ylides and Electron-Deficient Olefins

Molecules, 2023
[3 + 2] Cycloaddition reactions of heteroaromatic N-ylides with electron-deficient olefins have been developed. The heteroaromatic N-ylides, in situ generated from N-phenacylbenzothiazolium bromides, can smoothly react with maleimides under very mild ...
Zhen-Hua Wang, Tong Zhang, Li-Wen Shen, Xiu Yang, Yan-Ping Zhang, Yong You, Jian-Qiang Zhao, Wei-Cheng Yuan   +7 more
doaj   +1 more source

Rhodium catalyzed cascade cyclization featuring B-H and C-H activation: one-step construction of carborane-fused N-polyheterocycles. [PDF]

Chem Sci, 2018
A one-pot strategy for efficient and facile synthesis of C,B-substituted carborane-fused N-polyheterocycles is reported. A rhodium catalyzed cascade cyclization of carboranyl N-arylimines with vinyl ketones enables the effective construction of three new
Lyu H, Quan Y, Xie Z.
europepmc   +2 more sources

Metathesis Approach to the Synthesis of Polyheterocyclic Structures from Oxanorbornenes [PDF]

Organic Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Jeffrey D, Winkler, Sylvie M, Asselin, Stacey, Shepard, Jing, Yuan   +3 more
openaire   +2 more sources

Cationic Gold(I)-Catalyzed Cascade Bicyclizations for Divergent Synthesis of (Spiro)polyheterocycles

, 2020
We herein report an expeditious synthetic strategy to access diverse (spiro)polyheterocycles from easily available starting materials in two operational steps including an Ugi four-component reaction and a cationic gold(I)-catalyzed cascade bicyclization.
Song L., Tian G., Meervelt L.V., Li Z., Van Der Eycken E.V.   +4 more
core   +3 more sources

Photoinduced Phosphorylation/Cyclization of Cyanoaromatics for Divergent Access to Mono- and Diphosphorylated Polyheterocycles

, 2021
The visible-light-driven switchable phosphorylation of cyanoaromatics with the 1,6-enyne moiety for the diverse and selective synthesis of phosphorylated polyheterocycles, including phosphorylated aminophosphonates, iminophosphonates, and ketones, has ...
Yufei Yang (1851586), Zhipeng Zheng (5733500), Guo Tang, Yufei Yang, Yufen Zhao (144572), Shanshan Shi, Yumeng Zhang, Guo Tang (1478767), Shanshan Shi (524755), Denghui Ma, Yan Liu, Yumeng Zhang (3115050), Denghui Ma (9749397), Zhipeng Zheng, Yuzhen Gao, Yufen Zhao, Yan Liu (25061), Yuzhen Gao (287222)   +17 more
core   +1 more source

Metal- and light-free approach to polyheterocycles via a quinone-Cs2CO3 couple promoted regioselective cascade radical cyclization

Green Synthesis and Catalysis
A highly efficient, transition-metal- and light-free approach to polyheterocycles via regioselective cascade radical cyclization is developed. The redox-neutral protocol has a broad substrate scope with good functional group tolerance and probably ...
Qijing Zhang, Pan Yue, Hao Lei, Cong-Ying Zhou, Chengming Wang   +4 more
doaj   +1 more source