Results 41 to 50 of about 517 (172)

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization

Beilstein Journal of Organic Chemistry, 2012
A mild, efficient and versatile method has been developed for the construction of a functionalized natural product, meridianin, and its post conversion to pyrimido-β-carboline by cationic π- cyclization. The strategy involves the introduction of an amino
Piyush K. Agarwal, Meena D. Dathi, Mohammad Saifuddin, Bijoy Kundu   +3 more
doaj   +1 more source

One‐Pot Three‐Component Coupling Access to Indolizine‐Pyrrolodiazepine Hybrid Structures

Asian Journal of Organic Chemistry, Volume 14, Issue 6, June 2025.
One‐pot three‐component coupling of pyridine‐2‐acetonitrile, N‐substituted pyrrole‐2‐carboxaldehyde, and TMSCN in the presence of DBU allowed facile access to a novel indolizine‐pyrrolodiazepine hybrid structure via a domino aldol condensation‐Michael addition‐cycloisomerization‐imine formation process enabling sequential construction of two ...
Sunhee Lee, Seonghyeon Nam, Ikyon Kim
wiley   +1 more source

γ‐Terpinene: Biorenewable Reductant for the Molybdenum‐Catalyzed Reduction of Sulfoxides, N‐Oxides and Nitroarenes

Advanced Synthesis &Catalysis, Volume 367, Issue 9, May 6, 2025.
Abstract A molybdenum‐catalyzed deoxygenation of sulfoxides, pyridine and quinoline N‐oxides, N‐hydroxybenzotriazoles, as well as the reduction of nitroarenes to anilines, has been developed using monocyclic terpenes such as γ‐terpinene as an environmentally benign hydrogen surrogate.
Raquel Hernández‐Ruiz, Marta Solas, Samuel Suárez‐Pantiga, María R. Pedrosa, Roberto Sanz   +4 more
wiley   +1 more source

Synthesis of Natural Product-like Polyheterocycles via One-Pot Cascade Oximation, C–H Activation, and Alkyne Annulation

, 2016
An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was developed.
Yunhui Bin (2067283), Yunpeng Wang (172933), Ruimao Hua (1545895), Liyao Zheng (1545889)   +3 more
core   +3 more sources

Palladium‐Catalyzed [3+2+2] Cycloaddition Between Carbonyl‐Tethered Alkylidenecyclopropanes and Isocyanates

Helvetica Chimica Acta, Volume 108, Issue 5, May 2025.
Abstract Carbonyl‐tethered alkylidenecyclopropanes can react with aryl isocyanates in presence of Pd(0)‐phosphoramidite catalysts to give seven‐membered heterobicyclic products in a formal [3+2+2] cycloaddition process. The reaction involves the formation of a palladium π‐allyl complex intermediate (A), which behaves as a formal 1,5‐dipole, and can be ...
Ricardo Rodiño, Jose L. Mascareñas, Fernando López   +2 more
wiley   +1 more source

Multicomponent Synthesis of the New Compound 2-Benzyl-6-(3-((7-chloroquinolin-4-yl)amino)propyl)-3-morpholino-7-(4-pyridin-2-yl)phenyl)-6,7-dihidro-5H-pyrrolo[3,4-b]pyridin-5-one

Chemistry Proceedings
The combination of multicomponent reactions with post-transformation processes is a powerful strategy for the rapid synthesis of structurally complex polyheterocycles.
Roberto E. Blanco-Carapia, Rodolfo Alonso-Pérez, Alejandro Islas-Jácome, Eduardo Gonzalez-Zamora   +3 more
doaj   +1 more source

Ortho‐Quinone Methide Driven Synthesis of New O,N‐ or N,N‐Heterocycles

ChemistryOpen, 2019
To synthesize functionalized Mannich bases that can serve two different types of ortho‐quinone methide (o‐QM) intermediates, 2‐naphthol and 6‐hydroxyquinoline were reacted with salicylic aldehyde in the presence of morpholine.
Dr. István Szatmári, Khadija Belasri, Dr. Matthias Heydenreich, Dr. Andreas Koch, Prof. Dr. Erich Kleinpeter, Prof. Dr. Ferenc Fülöp   +5 more
doaj   +1 more source

2‐Aminoindoles and 2‐Iminoindolines as Viable Precursors of Indole‐Fused Nitrogenated Polyheterocycles

Advanced Synthesis &Catalysis, Volume 367, Issue 6, March 18, 2025.
Abstract The synthesis of architecturally complex polyheterocyclic structures embedding the indole ring represents a growing field of interest. Carbolines and their partially dehydro derivatives, pyrazinoindoles, indoloindoles, azepinoindoles and other medium‐sized derivatives are only some examples of indole‐containing polycyclic compounds featured by
Alessandro Palmieri, Marino Petrini
wiley   +1 more source

Metal Coordination-Induced Electronic Tuning in Fused Polyheterocycles: Synthesis and Characterization of Cu, Zn and Fe Complexes of Benzo[a]furo[2,3-c]phenazine, Furo[3′,2′:3,4]naphtho[1,2-d]imidazole and Naphtho[1,2-b]furan-4,5-dione

Chemistry
We report the synthesis, characterisation and electronic modulation of three novel fused polyheterocyclic ligands—naphtho[1,2-b]furan-4,5-dione (1), furo[3′,2′:3,4]naphtho[1,2-d]imidazole (2), and benzo[a]furo[2,3-c]phenazine (3)—and their Cu(II), Zn(II)
Zoltán Köntös, Máté Varga
doaj   +1 more source