Results 131 to 140 of about 65,761 (163)

Unexpected Cascade Sequence Forming the C(sp3)-N/C(sp2)-C(sp2) Bond: Direct Access to γ-Lactam-Fused Pyridones with Anticancer Activity.

Journal of Organic Chemistry, 2023
An unexpected Ugi cascade reaction was developed for the facile construction of γ-lactam-fused pyridone derivatives with high tolerance of substrates. A C(sp3)-N bond and a C(sp2)-C(sp2) bond were formed together, accompanied by a chromone ring-opening ...
Ya-Nan An, Jiuhong Huang, Shijia Xu, Xiao-Lin Wang, Cheng‐He Zhou, Zhigang Xu, J. Lei, Zhong-Zhu Chen   +7 more
semanticscholar   +1 more source

One-pot construction of functionalized aziridines and maleimides via a novel pseudo-Knoevenagel cascade reaction.

Chemical Communications, 2020
An Ugi, novel pseudo-Knoevenagel, ring expansion cascade reaction was discovered and utilized for the synthesis of aziridinyl succinimides in one-pot.
J. Lei, Gui-ting Song, Liu-Jun He, Yafei Luo, D. Tang, Hui-Kuan Lin, Brendan Frett, Hong‐yu Li, Zhong-Zhu Chen, Zhigang Xu   +9 more
semanticscholar   +1 more source

Expeditious access of chromone analogues via a Michael addition-driven multicomponent reaction

, 2020
A Michael addition-driven four-component reaction (4-CR) was developed for derivatizing chromones by strategically suppressing competing 4-CR Ugi reaction without a catalyst.
J. Lei, Yong Li, Liu-Jun He, Yafei Luo, D. Tang, Wei Yan, Hui-Kuan Lin, Hong‐yu Li, Zhong-Zhu Chen, Zhigang Xu   +9 more
semanticscholar   +1 more source

Hydrophobically Modified Alginate Derivatives via the Ugi Multicomponent Reaction for the Development of Hydrophobic Pharmaceutical Formulations

ChemistrySelect, 2021
Yanshi Wen, Xiuqiong Chen, Zhaowen Liu, Qingmei Zhu, Zhengyue Li, Guoqing He, Huiqiong Yan, Qiang Lin   +7 more
semanticscholar   +1 more source

One-Step Synthesis for Orn-Val with High Molecular Weight and Low Polydispersity by Ugi Four-Component Condensation.

ACS Biomaterials Science & Engineering
Basic amino acid alternating copolymers exhibit exceptional antimicrobial properties and biosafety, yet their application is restricted by the complexity of the synthesis process and low molecular weight (Mn = 1000). In this study, we synthesized a basic
Junhui Ma, Nan-qi Ma, Jun Liu, Qiongqiong Zhu, Yan Tang, Lei Wang, Yan Yan, Ting Yue, Meiyu Shao, Wei Zhang   +9 more
semanticscholar   +1 more source

Chiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct.

Angewandte Chemie, 2016
Yun Zhang, Y. Ao, Zhi-tang Huang, De‐Xian Wang, Mei-Xiang Wang, Jieping Zhu   +5 more
semanticscholar   +1 more source

Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction.

Bioorganic chemistry (Print), 2021
Xu Zhou, Meng-zhu Zheng, Na Zhao, Yixin Hu, Kaiyin Yang, Junfeng Huo, Guangyuan Liu, Jiangeng Huang, Lixia Chen, Yirong Zhou, Hua Li   +10 more
semanticscholar   +1 more source

Microwave-assisted facile construction of quinoxalinone and benzimidazopyrazinone derivatives via two paths of post-Ugi cascade reaction

Molecular diversity, 2018
Gui-ting Song, Yong Li, J. Xu, Zhigang Xu, Yong Ding, J. Lei, Nick McConnell, Jin Zhu, Zhong-Zhu Chen   +8 more
semanticscholar   +1 more source

Enantioselective Synthesis of Chiral 1,4‐Diynes via Copper‐Catalyzed Asymmetric Radical Alkynylation of Propargyl Chlorides

Chinese journal of chemistry
Chiral 1,4‐diynes serve as important synthetic building blocks; however, general and efficient catalytic asymmetric strategies for their direct assembly from readily available propargylic chlorides and alkynes remain underdeveloped. Herein, we report
Aoping Zhu, Haohao Han, Yuhongxu Bai, Kailun Liang, Jun Jiang, Caiyou Chen   +5 more
semanticscholar   +1 more source

An Efficient Nickel-Catalyzed Asymmetric Oxazole-Forming Ugi-Type Reaction for the Synthesis of Chiral Aryl-Substituted THIQ Rings.

Chemistry, 2017
Dan Li, Dongxu Yang, Linqing Wang, Xihong Liu, Kezhou Wang, Jie Wang, Pengxin Wang, Yuyang Liu, Haiyong Zhu, Rui Wang   +9 more
semanticscholar   +1 more source