Results 81 to 90 of about 2,976,642 (307)

Head-to-Head Comparison of UHPLC-MS/MS and Alinity C for Plasma Analysis of Risperidone and Paliperidone

Pharmaceuticals
Background and objectives: Risperidone, a second-generation antipsychotic widely used in the treatment of schizophrenia, requires therapeutic drug monitoring due to its high interindividual variability.
Francisco José Toja-Camba, Gonzalo Hermelo-Vidal, Carolina Feitosa-Medeiros, María Vidal-Millares, María José Durán-Maseda, Anxo Fernández-Ferreiro, Cristina Mondelo-García   +6 more
doaj   +1 more source

UHPLC-MS/MS for plasma lamotrigineanalysis and comparison with a homogenousenzyme immunoassay: supplementary data

Aims: To develop and validate a UHPLC-MS/MS method for lamotrigine (LTG) analysis in human plasmaand evaluate its agreement with a homogenous enzyme immunoassay (HEIA).
Xiaoxu Shi (8560299), Shenghui Mei (3478874), Dongjie Zhang (2410159), Zhigang Zhao (288127)   +3 more
core   +1 more source

UHPLC-QTOF-MS/MS based characterization of anti-tumor constituents in Ceratocarpus arenarius L. and identification of EGFR-TK inhibitors by virtual screening

, 2022
The constituents of Ceratocarpus arenarius L., as a traditional anticancer medicine of Kazakh, were firstly profiled with UHPLC-QTOF-MS/MS. The potential compounds against EGFR-TK were virtually screened.
Le Pan (417679), Jiaojiao Zhang (3184836), JinMen Yu (12327147), Jiashan Li (12327144), Ming Gao (115719), Lu Jin (448623), Dongyu Lei (7520867), Lu Xu (386491), Li Li (14993)   +8 more
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Development of an analytical method for the quantification of isoflavones in legumes by SPE-UHPLC-MS/MS

, 2013
Legumes include lentils, beans, chickpeas, fava beans, soy beans and others. Cultivated for thousands of years, they have played an important role in the traditional diets of many regions throughout the world. A new method, that consists of an extraction
Gianni Sagratini, Sauro Vittori, Pilar Vila Donat, Massimo Ricciutelli, Filippo Maggi, Elisabetta Torregiani, Giovanni Caprioli, Manuela Cortese   +7 more
core   +1 more source

Determination and Pharmacokinetic Study of Three Diterpenes in Rat Plasma by UHPLC-ESI-MS/MS after Oral Administration of Rosmarinus officinalis L. Extract

Molecules, 2017
Rosmarinus officinalis L. is commonly used as a spice and flavoring agent. Diterpenes are the main active compounds of R. officinalis. An Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-ESI-MS/MS) method was developed for the
Liqian Wang, Chunli Gan, Zhibin Wang, Lu Liu, Mingjie Gao, Qian Li, Chunjuan Yang   +6 more
doaj   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Rapid and comprehensive evaluation of (poly)phenolic compounds in pomegranate (punica granatum L.) juice by UHPLC-MSn [PDF]

, 2012
The comprehensive identification of phenolic compounds in food and beverages is a crucial starting point for assessing their biological, nutritional, and technological properties.
Bruni, Renato, Luca Calani, Galaverna, Gianni, Cristina García-Viguera, Mena, P., Renato Bruni, Dall'Asta, C., Calani, Luca, Crozier A, DEL RIO, Daniele, Pedro Mena, Alan Crozier, Bruni, R., MENA PARRENO, Pedro Miguel, Garcia Viguera C, García-Viguera, C., Dall'Asta, Chiara, Chiara Dall'Asta, Mena, Pedro, Gianni Galaverna, Crozier, A., Daniele Del Rio, Chiara Dall\u27Asta, Calani, L., García-Viguera, Cristina, Rio, Daniele del, Del Rio, D., Galaverna, G., Crozier, Alan   +28 more
core   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source