Results 131 to 140 of about 2,523,217 (244)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Inequalities in the UK [PDF]

Journal of the Royal Society of Medicine, 2001
openaire   +2 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

National survey of protocols for day-case hip and knee arthroplasty in the UK. [PDF]

Bone Jt Open
Edwards TA, Large J, French JMR, Evans JT, Reed MR, Whitehouse MR, Day Case Collaborative, Ng ABY, Hosea A, Pradhan A, Date A, Charalambous A, Hunt A, Nakhla A, Firth AM, Metry A, Bolland BJ, Aliker C, Navaratnam DM, Waugh D, Ojelade E, Morriss F, Chadalavada G, Slade G, Higgins G, Neal-Smith G, Umer HM, Noone H, Rankin I, Muhammad I, Ahmed I, Morris J, Roberts J, Hill J, Quayle J, Topping J, Heylen J, Howard J, Moreau J, Roope J, Cumberworth J, Logishetty K, Hogan K, Khilla K, Syam K, Patel K, Kaushik Dash K, Sinan L, Jenner L, Girling L, Choi M, Andrews M, Gibby M, Petrie M, Wilson M, Mubashir Siddiqui M, Bhaskara NV, Flannery O, Kabariti R, Ashour R, Sinnerton R, Azeez S, Everett SJ, Miller S, Hermena S, Mehta S, Bannagham S, Mannan S, Khaleeq T, Maunganidze T, Petheram T, Ross Fraser T, Ng Z.   +72 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Overview of findings from the UK and Ireland National Advanced Heart Failure Audit 2024. [PDF]

Open Heart
Dar O, Dulay MS, Pettit SJ, Bhagra SK, Chue C, Payne JR, Dalzell JR, McDiarmid AK, Gonzalez-Fernandez O, Shaw SM, Callan P, Hooper J, Joyce E, Sullivan V, McDonagh T, Jenkins GH, Ellis GR, Campbell P, Anderson LJ, Lim S.   +19 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Plasma protein signatures altered before and after tuberculosis diagnosis in a population-based cohort. [PDF]

Clin Proteomics
Koziar N, Whetton AD, Geifman N.
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source