Results 191 to 200 of about 9,979,066 (266)

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Characterising Hepatitis D Virus in the UK From 2011 to 2021. [PDF]

J Viral Hepat
Simmons R, Ijaz S, Jackson R, Jack K, Mulongeni R, Raghu R, Riddell A, Elsharkawy A, Uriel A, Koffas A, Chaika A, Lawson A, Cole A, McEwan A, Brown A, Stone B, Levick C, Byrne D, Forton D, MacDonald D, Forde D, Nastouli E, Barnes E, Sumner E, Page E, Carey I, Vilar FJ, Maggs J, Collier J, Shepherd J, Agarwal K, Bicknell K, Ala K, Dear K, Ratcliffe L, Bruce M, Zhang H, Rivett L, Maes M, Ankcorn M, Aldersley M, Prince M, Lemoine M, Foxton M, Wright M, Cramp M, Wiselka M, Easom N, Richardson P, Gunson R, Herbert R, Blackwell R, Jelley R, Aspinall R, Simpson R, Clewes R, Ahmad S, Mcpherson S, Ryder S, Verma S, Lampejo T, Sathyanarayana V, Gelson W, Leeman D, Desai M, Mandal S, Kennedy PT, Irving WL.   +67 more
europepmc   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Nutritional Safety and Health Resilience in Europe: Declining Micronutrient Intakes, Widening Distributional Disparities and Persistent Inadequacies Revealed from National Dietary Surveys. [PDF]

Nutrients
Christie S, Gombart AF, Hill TR, You T, Calder PC.   +4 more
europepmc   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Hypertensive Disorders of Pregnancy and Cardiovascular-Kidney-Metabolic Syndrome. [PDF]

Hypertension
Ezzat D, Pabon MA, Li L, Chang A, De Moor N, Yu Z, Cho SMJ, Natarajan P, Spracklen CN, LeBlanc ES, Eaton CB, LaMonte MJ, Stefanick ML, Manson JE, Parikh N, Reiner AP, Roh JD, Soria-Contreras DC, Hoshi RA, Mora S, Demler OV, Powe CE, Honigberg MC.   +22 more
europepmc   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Open-label, randomised controlled, multicentre study evaluating higher valency pneumococcal vaccines (PCV15/PCV20) compared with PCV13 given in homologous schedules at 3 months and 12 months ('1+1' schedule) and 2 months, 4 months and 12 months ('2+1' schedule) in infants: protocol. [PDF]

BMJ Open
Aslam R, Akeju O, Clutterbuck E, Appleby C, Murphy D, De Calignon A, Muller J, White R, Singha A, Mujadidi YF, Roderick M, Turner DPJ, Heath PT, Owens D, Goldblatt D, Ebrahimi N, Liu X, Faust S, Ramasamy MNN, Kelly D.   +19 more
europepmc   +1 more source