Results 51 to 60 of about 7,495,371 (267)
Efficacy and Mechanism Evaluation, 2021 Background: Aneurysmal subarachnoid haemorrhage is a major cause of haemorrhagic stroke. The incidence is ≈ 80 per million population per year; it peaks in the 40–60 years age range and often has a poor prognosis with the outcome linked to severity of ...
Philip White +10 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
A follow-up evaluation of the business growth through skills development and knowledge transfer project [PDF]
, 2010 Builds on earlier (2008) evaluation of the Business Growth through Skills Development and Knowledge Transfer Programme, delivered through the New Technology Institute (NTI) in the East Midlands. This evaluation focuses on the programme's third and final
ekosgen consulting (UK) Ltd.
core
Fault detection and diagnosis of a plastic film extrusion process [PDF]
, 2010 This paper presents a new approach to the design of a model-based fault detection and diagnosis system for application to a plastic film extrusion process. The design constructs a residual generator via parity relations.
DuPont Teijin Films UK Ltd (Funder) +4 more
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Anti-Trafficking Review, 2015 The focus of this article is on advocacy opportunities provided by the anti-trafficking framework in a new political climate. Through the case study of the United Kingdom (UK) Modern Slavery Act 2015 deliberations the article explores opportunities to ...
Caroline Robinson
doaj +1 more source
Teaching the changing story [PDF]
, 2007 This paper begins with a brief survey of the state of contemporary short fiction practice, with particular reference to McSweeneys Quarterly Concern, leading into a reflective account of pedagogical approaches to short fiction on Creative Writing degree ...
Hurley, UK
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source