Results 81 to 90 of about 7,495,371 (267)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
European Papers, 2016 (Series Information) European Papers - A Journal on Law and Integration, 2016 1(2), 621-635 | European Forum Insight of 22 August 2016 | (Table of Contents) I. Introduction. - II. The foundation of NAPs roadmap: the 2011 United Nations guiding principles
Marco Fasciglione
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
UK Seabirds in 2005 : results from the UK Seabird Monitoring Programme [PDF]
, 2009 Seabirds in the UK were generally more productive in 2005 than in 2004, when productivity for many species reached an all-time low. A presumed scarcity of sandeels in 2004, especially in the North Sea, led to widespread starvation of chicks in the ...
Parsons, Matthew
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
THE EUROPEAN UNION AND THE PROBLEM OF RECOGNIZING «PALESTINIAN STATE» [PDF]
Научно-аналитический вестник Института Европы РАНThis article analyzes the essence of France’s high-profile and large-scale initiative, supported by Great Britain and several EU states, to recognize the «independent Palestinian state».
Alexander I. Shumilin
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རྒྱང་རིང་ནས་ཡོང་བའི་གྲོགས་པོ། [PDF]
, 2011 .wav audio fileThis song is sung during the New Year period and says, “We relatives and friends will all gather beside the stove. The youths will sit beside the stove and the elders will teach them Pumi customs and culture.
Hu Qianma
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Rare Primary Pelvic Hydatid Cyst Presenting as Sciatica [PDF]
, 2012 Primary hydatid cyst in the pelvis is rare, and usually presents with pressure symptoms affecting the adjacent abdominal organs. We describe a rare hydatid cyst which was eroding the sacral hallow, protruding into the right sciatic foramen and presenting
Bafna, UD +3 more
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