Results 201 to 210 of about 20,711,708 (259)

Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and Mendelian randomization. [PDF]

Alzheimers Dement
Chatterjee A, Alvarez B, Sharma RU, Jonson C, Wilkins HM, Pa J, Swerdlow RH, Goate A, Yaffe K, Andrews SJ, Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative.   +10 more
europepmc   +1 more source

Kinematic Features of Voluntary and Involuntary Head Movements in Cervical Dystonia

Movement Disorders, EarlyView.
Abstract Background Cervical dystonia (CD) has a varied motor presentation, combining abnormal postures with complex involuntary head movements. Classification of these motor patterns remains imprecise, relying on descriptive terminology without robust definitions. Objectives To provide a kinematically‐grounded description of the motor phenomenology of
Thomas Hart, Davide Martino, Larissa R. Heideman, Martijn Beudel, Mark J. Edwards, Anna Sadnicka, Francesca Morgante   +6 more
wiley   +1 more source

Empowering Medical Affairs Professionals in Their Critical Role in Integrated Evidence Generation Planning. [PDF]

Pharmaceut Med
Nelissen J, Williams A, James C, Male G.
europepmc   +1 more source

High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena, Anna Delamarre, Miguel Lopez‐Cuina, Hugo Martin, Elio Balpe, Xavier Fioramonti, Erwan Bezard, Wassilios G. Meissner   +7 more
wiley   +1 more source

Prescribing Patterns and Clinical Outcomes of Ceftolozane/Tazobactam by Renal Function and Body Mass Index: A SPECTRA Real-World Multi-Country Analysis. [PDF]

Antibiotics (Basel)
Yucel E, Soriano A, Thalhammer F, Kluge S, Allen M, Levy J, Yang H, Kaul S.   +7 more
europepmc   +1 more source

DNA Repair Pathway Variants Are Enriched in Individuals with Biallelic AAGGG CANVAS and RFC1‐Related Disease

Movement Disorders, EarlyView.
Abstract Background Cerebellar ataxia, neuropathy and vestibular are flexia syndrome (CANVAS) and RFC1‐related disease are most commonly caused by biallelic AAGGG repeat expansions in RFC1. The high population frequency of this expansion compared to the frequency of CANVAS suggests incomplete penetrance.
Xuemin Wang, Liam G. Fearnley, Kayli C. Davies, Penny Snell, Stuart Lee, Victoria E. Jackson, Justin Read, Michael Milton, Ian H. Harding, Martin B. Delatycki, David J. Szmulewicz, Paul J. Lockhart, Melanie Bahlo, Haloom Rafehi   +13 more
wiley   +1 more source

Poor sleep is robustly correlated with accelerated aging but the evidence for causation is mixed

Whitman ET, Prather AA, Mutz J, Arseneault L, Baranger DA, Elliott ML, Fisher HL, Ireland D, Knodt AR, Kositzke C, Leng Y, Reuben A, Sugden K, Williams BS, Xie JK, Yuan A, Moffitt TE, Caspi A, Hariri AR, the Alzheimer's Disease Neuroimaging Initiative.   +19 more
europepmc   +1 more source

Exploring longitudinal relationships among Alzheimer's disease biomarkers. [PDF]

Alzheimers Dement
Saef B, Petersen KK, Volluz K, Li Y, Tosun D, Mila-Aloma M, Shaw LM, Zetterberg H, Dage JL, Rubel CE, Ferber K, Du-Cuny L, Coomaraswamy J, Baratta M, Mordashova Y, Saad ZS, Triana-Baltzer G, Ashton NJ, Meyers EA, Rosenbaugh EG, Sabandal JM, Bannon AW, Potter WZ, Alzheimer's Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team, Schindler SE.   +25 more
europepmc   +1 more source

Factors affecting outdoor time and screentime in the context of preschool myopia prevention: a mixed-methods study. [PDF]

Eye (Lond)
Khutan S, McLean RJ, Thomas MG, Rufai SR.   +3 more
europepmc   +1 more source