Results 141 to 150 of about 558,447 (316)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Photographic Work Exhibited in 'In the Blink of an Eye: Media and Movement,' National Media Museum, Bradford, UK, (9 March – 14 October 2012)

, 2012
Photographic work from Billingham's series 'Rays a Laugh' was exhibited in 'In the Blink of an Eye: Media and Movement,' National Media Museum, Bradford, UK, (9 March – 14 October 2012).
National Media Museum, Bradford, Billingham, Richard   +1 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Perceptions of school children of using social media for learning

, 2014
Social media is lauded as a powerful tool for informal learning, and a tool of choice for teenagers. This paper reports on the findings of a survey of 384 secondary school pupils in the UK (aged 11-17) over a 12 week period.
Woollard, John, Millard, David, Blair, Robert   +2 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

‘Now There Is Somebody I Can Go to, Although It’s an AI’: Evaluating Acceptance and Use of Obruche, a Pilot Chatbot to Prevent Power Asymmetries in Cross-Border Journalism Teams

Journalism and Media
This exploratory study examines how journalists in/coordinating investigations use a chatbot designed to reduce power asymmetries during remote work.
Ruona Meyer
doaj   +1 more source

The UK media report for war [PDF]

British Journalism Review, 2020
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Fourth Estate in the USA and UK [PDF]

, 2011
This thesis examines the ways in which political journalists in the USA and UK talk about issues of truth and power as it relates to journalism‟s role as the Fourth Estate.
Hearns-Branaman, Jesse Owen
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source