Results 131 to 140 of about 7,857,664 (291)
Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer
Advanced Science, EarlyView.The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu +13 more
wiley +1 more source
A Century of Immigration Rhetoric in the UK Parliament
Migration is a defining phenomenon of our time, around which heightened political rhetoric creates the impression of unprecedented political conflict. In the UK, this perception coincides with major political developments, such as the Brexit referendum and the rise of anti-immigration politics in recent decades.
Gloria Gennaro +7 more
openaire +1 more source
Advanced Science, EarlyView.Nanoscale secondary ion mass spectrometry (Nano SIMS) is established as a powerful analytical tool to visualize and quantify the membrane fouling layers. ABSTRACT Membrane technology has garnered considerable attention for applications in wastewater treatment and resource recovery. Nevertheless, membrane fouling remains a major barrier, yet the lack of
Mengfei Wu +4 more
wiley +1 more source
Brexit: The Relationship between the UK Parliament and the UK Government
, 2017 The structure of this work is specifically designed to offer the clearest presentation of these analyses and constitute a critical, comprehensive resource on the effects of de-Europeanisation on the UK legal system.
openaire
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Iatrogenic Cushing’s syndrome from topical steroid use
European Journal of Rheumatology, 2022 Vivek Arya +2 more
doaj +1 more source
Regulatory Compliance and Web Accessibility of UK Parliament Sites [PDF]
J. Inf. Law Technol., 2009 This research seeks to review whether web accessibility and disability laws lead to strong compliance among UK e-government web sites. This study samples 130 sites of the UK members of Parliament using an online accessibility testing tool and determines if the site design complies with disability laws and Web Content Accessibility Guidelines (WCAG ...
openaire +1 more source
A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics
Advanced Science, EarlyView.A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma +22 more
wiley +1 more source
Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform
Advanced Science, EarlyView.Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao +10 more
wiley +1 more source