Results 141 to 150 of about 25,886 (305)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Regulatory Compliance and Web Accessibility of UK Parliament Sites [PDF]

J. Inf. Law Technol., 2009
This research seeks to review whether web accessibility and disability laws lead to strong compliance among UK e-government web sites. This study samples 130 sites of the UK members of Parliament using an online accessibility testing tool and determines if the site design complies with disability laws and Web Content Accessibility Guidelines (WCAG ...
openaire   +1 more source

Written submission (ATJ0163) to the Parliament Justice Committee - Access to Justice [PDF]

This submission is to be read in conjunction with Dr Curran’s Submission to the House of Lords Constitution Committee - Inquiry into the Rule of Law (2025); Submission to the UK Parliament Public Accounts Committee – Value for Money from Legal Aid (2024);
Curran, L
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A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Iatrogenic Cushing’s syndrome from topical steroid use

European Journal of Rheumatology, 2022
Vivek Arya , Ashish Sharma, Mohammad Ali   +2 more
doaj   +1 more source

Online Safety Bill (2022)

, 2022
UK Parliament
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Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source

Strategic Ignorance and Interests in the UK Parliament

International Journal of Parliamentary Studies
Abstract Elected UK mp s claim to represent our interests, for which they need to know our preferences within our social contexts, while peers in the House of Lords position themselves as knowledgeable experts. Parliaments are institutional knowledge producers and disseminators, but their knowledge will always be partial.
openaire   +1 more source

Addressing candidate security in contemporary election campaigns

© 2025 UK Parliament. Written evidence submitted to the Speaker’s Conference on the security of candidates, MPs and elections, UK Parliament, available online: https://committees.parliament.uk/writtenevidence/137322 ...
Blamire, Joshua, Banducci, Susan, van Zijl, Julia, Tirado Castro, Alejandro, Fagin, Jessica, Tyler, Katharine   +5 more
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