Results 1 to 10 of about 664,080 (329)

catmap:

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ase-control

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nd

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DT

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eta-

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nalysis

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ackage [PDF]

BMC Bioinformatics, 2008
Background Risk for complex disease is thought to be controlled by multiple genetic risk factors, each with small individual effects. Meta-analyses of several independent studies may be helpful to increase the ability to detect association when effect ...
Nicodemus Kristin K
doaj   +3 more sources

MATRICS: A

M

ethod for

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ggregating

T

he

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eporting of

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nterventions in

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omplex

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tudies [PDF]

Trials, 2011
Background There are few rigorous methods for combining qualitative and quantitative findings from studies with complex interventions using multiple research methods and giving appropriate weight to each without introducing bias to the overall conclusions. We developed a Method for Aggregating The Reporting of Interventions in Complex Studies (MATRICS)
Thorne Kymberley, Jerzembek Gabi S, Cheung Wai-Yee, Cohen David, Hutchings Hayley A, Rapport Frances L, Seagrove Anne C, Williams John G, Russell Ian T   +8 more
doaj   +5 more sources

Rationale and design of a prospective study:

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ervical

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ystonia

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atient

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egistry for

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bservation of

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na

B

otulinumtoxinA

E

fficacy (CD PROBE) [PDF]

BMC Neurology, 2011
Background A registry of patients with cervical dystonia (Cervical Dystonia Patient Registry for Observation of onaBotulinumtoxinA Efficacy [CD PROBE]) was initiated to capture data regarding physician practices and patient outcomes with ...
Schwartz Marc, Stacy Mark, Comella Cynthia, Charles P David, Adler Charles H, Jankovic Joseph, Sutch Susan M, Brin Mitchell F, Papapetropoulos Spyridon   +8 more
doaj   +5 more sources

IPAD: the

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ntegrated

P

athway

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nalysis

D

atabase for Systematic Enrichment Analysis [PDF]

BMC Bioinformatics, 2012
Background Next-Generation Sequencing (NGS) technologies and Genome-Wide Association Studies (GWAS) generate millions of reads and hundreds of datasets, and there is an urgent need for a better way to accurately interpret and distill such large amounts ...
Zhang Fan, Drabier Renee
doaj   +3 more sources

AutoFACT: An

Auto

matic

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unctional

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nnotation and

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lassification

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ool [PDF]

BMC Bioinformatics, 2005
Background Assignment of function to new molecular sequence data is an essential step in genomics projects. The usual process involves similarity searches of a given sequence against one or more databases, an arduous process for large datasets.
Lang B Franz, Gray Michael W, Koski Liisa B, Burger Gertraud   +3 more
doaj   +3 more sources

CLARITY:

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hi

L

dhood

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rthritis

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isk Factor

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dentification S

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ud

Y

. Investigating the role of aberrant DNA methylation in juvenile idiopathic arthritis [PDF]

Pediatric Rheumatology Online Journal, 2011
Background Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disorder likely to be determined by multiple genetic and environmental factors. Mounting evidence shows that epigenetic variation influences autoimmune disease risk. The most well-studied epigenetic mark is DNA methylation; increased methylation of CpG dinucleotides can reduce gene ...
Allen R, Akikusa J, Lim B, Ponsonby AL, Gordon L, Chavez R, Ellis JA, Saffery R, Craig J, Munro JE   +9 more
doaj   +2 more sources

The

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unctional

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ssessment of

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hronic

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llness

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herapy (FACIT) Measurement System: properties, applications, and interpretation

Health and Quality of Life Outcomes, 2003
The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System is a collection of health-related quality of life (HRQOL) questionnaires targeted to the management of chronic illness.
Yost Kathleen, Cella David, Webster Kimberly   +2 more
doaj   +3 more sources

M

ulticenter random

i

zed trial of cell t

he

rapy in c

ar

diopa

t

hies – MiHeart Study [PDF]

Trials, 2007
Background Cardiovascular diseases are the major cause of death in the world. Current treatments have not been able to reverse this scenario, creating the need for the development of new therapies.
Oliveira Sérgio A, Vilas-Boas Fábio, Feitosa Gilson, Krieger José E, Dohmann Hans F, dos Santos Ricardo, Gowdak Luis H, Martino Helena F, Tura Bernardo R, Silva Suzana A, Bozza Augusto Z, Borojevic Radovan, de Carvalho Antonio   +12 more
doaj   +3 more sources

Design of the RINSE Trial: The

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apid

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nfusion of cold

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ormal

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alin

e

by paramedics during CPR [PDF]

BMC Emergency Medicine, 2011
Background The International Liaison Committee on Resuscitation (ILCOR) now recommends therapeutic hypothermia (TH) (33°C for 12-24 hours) as soon as possible for patients who remain comatose after resuscitation from shockable rhythm in out-of-hospital ...
Jacobs Ian, Cameron Peter, Bernard Stephen, Deasy Conor, Smith Karen, Hein Cindy, Grantham Hugh, Finn Judith   +7 more
doaj   +6 more sources

W

ean

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arlier and

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utomatically with

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ew technology (the

WEAN

study): a protocol of a multicentre, pilot randomized controlled trial [PDF]

Trials, 2009
Background Weaning is the process during which mechanical ventilation is withdrawn and the work of breathing is transferred from the ventilator back to the patient.
Lessard Martin R, Meade Maureen O, Burns Karen EA, Keenan Sean P, Lellouche Francois   +4 more
doaj   +4 more sources