Results 41 to 50 of about 258,695 (237)

‘Modified Phallourethroplasty’ as a Surgical Alternative to Phalloplasty With Urethral Lengthening: Technique, How We Present This Option to Patients, and Clinical Outcomes

Sexual Medicine, 2022
Background: Most complications after masculinizing genital gender-affirming surgery (gGAS) are associated with urethral lengthening (+UL). While many transmasculine patients desire +UL for standing urination, not all patients prioritize this benefit over
Shannon M. Smith, MD, MPH, Nance Yuan, MD, Grace Lee, PA-C, Jenna Stelmar, BS, Edward Ray, MD, Maurice M. Garcia, MD, MAS   +5 more
doaj   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Is acupuncture a useful adjunct to physiotherapy for older adults with knee pain?: The "

A

cupuncture,

P

hysiotherapy and

Ex

ercise" (APEX) study [ISRCTN88597683]

BMC Musculoskeletal Disorders, 2004
Background Acupuncture is a popular non-pharmacological modality for treating musculoskeletal pain. Physiotherapists are one of the largest groups of acupuncture providers within the NHS, and they commonly use it alongside advice and exercise. Conclusive
Foster Nadine, Barlas Panos, Hay Elaine, Hill Jonathan, Thomas Elaine, Young Julie   +5 more
doaj   +1 more source

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the

C

hildren with

H

IV

E

arly Anti

r

etroviral Therapy (CHER) Study

BMC Research Notes, 2011
Background Although otorrhea occurs commonly in HIV-infected infants, there are few data. We compared the incidence of otorrhea in infants receiving early vs deferred ART in the Children with HIV Early Antiretroviral (CHER) trial.
Cornell Morna, van Rensburg Anita, Dobbels Els, Rabie Helena, Nachman Sharon, Sorour Gill, Taliep Reghana, Hainline Clotilde, Violari Avy, Madhi Shabir A, Cotton Mark F   +10 more
doaj   +1 more source

Urinary phytoestrogens and the risk of uterine leiomyomata in US women

BMC Women's Health, 2023
Background Uterine leiomyomata (UL) is a common gynecological disease in women. Studied on the relationship between single metabolites of urinary phytoestrogens and UL, especially for the combined effects of mixed metabolites on UL still are insufficient.
Fang Yang, Youguo Chen
doaj   +1 more source

Sensor-Based Categorization of Upper Limb Performance in Daily Life of Persons With and Without Neurological Upper Limb Deficits

Frontiers in Rehabilitation Sciences, 2021
Background: The use of wearable sensor technology (e. g., accelerometers) for tracking human physical activity have allowed for measurement of actual activity performance of the upper limb (UL) in daily life.
Jessica Barth, Keith R. Lohse, Jeffrey D. Konrad, Marghuertta D. Bland, Marghuertta D. Bland, Marghuertta D. Bland, Catherine E. Lang, Catherine E. Lang, Catherine E. Lang   +8 more
doaj   +1 more source

Mechanisms of Degradation in Li‐Ion Batteries Under Low Temperature Exposures

Advanced Functional Materials, EarlyView.
Low‐temperature exposures, or freeze‐thaw cycles, are observed to significantly accelerate the degradation of Li‐ion batteries. A combination of electrolyte phase separation and mechanochemical stress leads to reversible and irreversible performance losses.
Mihir Ojha, Shervin Alaei, Jayanth Ramamurthy, Luke P. Lounsbury, Md Mahdi Ul Ishtiaque, Stuart Leland, Niraj P. Atale, Sourav Das, Siddhartha Pathak, Pranav Shrotriya, Steve W. Martin, Todd A. Kingston, Cary L. Pint   +12 more
wiley   +1 more source

Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin

BMC Cell Biology, 2011
Background The amyloid precursor protein (APP) is cleaved by β- and γ-secretases to generate toxic amyloid β (Aβ) peptides. Alternatively, α-secretases cleave APP within the Aβ domain, precluding Aβ formation and releasing the soluble ectodomain, sAPPα ...
Slack Barbara E, Blusztajn Jan K, Carey Robyn M   +2 more
doaj   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source