Results 31 to 40 of about 287,233 (268)

Potential of herbal formulas and bioactive metabolites in treating atherosclerosis: targeted modulation of macrophage polarization

Frontiers in Pharmacology
Macrophage polarization plays a pivotal role in the pathogenesis and plaque stability of atherosclerosis (AS). In response to microenvironmental cues, macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes, which ...
Shixin Liu, Jinpeng Jing, Yunsha Zhang, Yunsha Zhang, Junchao Sun, Junchao Sun, Junchao Sun, Chaojun Zhu, Chaojun Zhu, Chaojun Zhu   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The combined impact of chronic kidney disease and ulcer severity on incident cardiovascular events in patients with diabetes‐related foot ulceration

Physiological Reports
In patients with diabetes‐related foot ulceration (DFU), ulcer severity and chronic kidney disease (CKD) portend worse outcomes. We evaluated the combined impact of a severe ulcer with CKD on major adverse cardiovascular events (MACE) in patients with ...
Nick S. R. Lan, Jonathan Hiew, Ivana Ferreira, J. Carsten Ritter, Laurens Manning, P. Gerry Fegan, Emma J. Hamilton, Girish Dwivedi   +7 more
doaj   +1 more source

The treatment of neurotrophic foot and ankle deformity of spinal bifida: 248 cases in single center

Journal of Neurorestoratology, 2019
Objective:To evaluate the functional outcome of foot and ankle deformity secondary to spinal bifida treated by various methods.Methods:A retrospective analysis of 248 patients with foot and ankle deformity secondary to spina bifida with an average age of
Jiancheng Zang, Sihe Qin, Vigneshwaran P, Lei Shi, Xulei Qin   +4 more
doaj   +1 more source

Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration

EBioMedicine, 2021
: Background: Low-dose aspirin can cause gastric and duodenal ulceration, hereafter called peptic ulcer disease (PUD). Predisposition is thought to be related to clinical and genetic factors; our aim was to identify genetic risk factors associated with ...
Stephane Bourgeois, Daniel F. Carr, Crispin O. Musumba, Alexander Penrose, Celestine Esume, Andrew P. Morris, Andrea L. Jorgensen, J. Eunice Zhang, D. Mark Pritchard, Panos Deloukas, Munir Pirmohamed   +10 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

La nomenclatura latina delle componenti della piaga dall’antichità classica a Thomas Linacre

Pallas, 2020
This paper concerns the history of the components of the ulcer from Hippocrates to the Renaissance in Greek, Latin, Arabic, Medieval Latin, Humanistic Latin, in its continuity and innovations.
Ivan Garofalo
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A randomized controlled trial of Shengji ointment combined with bromelain in promoting healing of tendon-exposed diabetic foot wounds: integrated 16S rDNA sequencing and metabolomics analysis

Frontiers in Pharmacology
BackgroundDiabetic foot tendon exposures are prone to infection, necrosis, and prolonged treatment cycle, not only hinder wound healing, but may also lead to amputation and even life-threatening. Utilizing Shengji ointment (a Traditional Chinese Medicine,
Xu Sun, Xu Sun, Xu Sun, Jielin Song, Jielin Song, Jielin Song, Junchao Sun, Junchao Sun, Junchao Sun, Zhaohui Zhang, Zhaohui Zhang, Zhaohui Zhang   +11 more
doaj   +1 more source

EXPERIMENTAL AND CLINICAL JUSTIFICATION WOUND-HEALING EFFECT OF BIOPLASTIC COLLAGEN MATERIAL IN THE TREATMENT OF CHRONIC WOUNDS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2021
Background. Due to the high prevalence of chronic wounds in patients with diabetes mellitus, the use of effective treatment for them is currently very important. Aim.
Dibirov M. D. , Gadzhimuradov R. U., Gabitov R. B. , Hlutkin A. V.   +3 more
doaj   +1 more source