Results 11 to 20 of about 522,036 (354)

Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin decoction on ulcerative Colitis

open access: yesScientific Reports, 2022
Huangqin decoction (HQD) is a Traditional Chinese Medicine formula for ulcerative colitis. However, the pharmacology and molecular mechanism of HQD on ulcerative colitis is still unclear.
Yi Wu, Xinqiao Liu, Guiwei Li
doaj   +2 more sources

Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis [PDF]

open access: yesArchives of Razi Institute, 2021
Inflammatory bowel disease (ulcerative colitis and Crohn’s disease) is a remitting and relapsing disease that affects millions of people worldwide. In the intestine, homeostasis between repair and signaling of the proinflammatory of the immune system is ...
A Falah Alshimerry   +2 more
doaj   +1 more source

Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis.

open access: yesNew England Journal of Medicine, 2021
BACKGROUND Ozanimod, a selective sphingosine-1-phosphate receptor modulator, is under investigation for the treatment of inflammatory bowel disease. METHODS We conducted a phase 3, multicenter, randomized, double-blind, placebo-controlled trial of ...
W. Sandborn   +15 more
semanticscholar   +1 more source

The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe

open access: yesBMC Gastroenterology, 2021
Background Ulcerative colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients.
Leonardo Ruiz-Casas   +14 more
doaj   +1 more source

Multi-omics analyses of the Ulcerative Colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

open access: yesNature Microbiology, 2021
Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current treatments exclusively target host inflammatory pathways. To understand how host–microbiota interactions become disrupted in UC, we collected and analysed six ...
R. Mills   +22 more
semanticscholar   +1 more source

Modern principles of conservative treatment of mild and moderate forms of ulcerative colitis

open access: yesЛечащий Врач, 2022
Ulcerative colitis is a chronic disease characterized by inflammation that usually begins in the rectum and diffusely spreads proximally, involving part or all of the colonic mucosa.
O. V. Golovenko
doaj   +1 more source

Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel

open access: yesScientific Reports, 2021
Ulcerative colitis is a chronic, idiopathic, and inflammatory disease of the rectal and colonic mucosa, the behavior of which is of heterogeneity in individuals.
Lijie Lai   +4 more
doaj   +1 more source

Oral manifestation of ulcerative colitis [PDF]

open access: yesStomatološki glasnik Srbije, 2022
Introduction Ulcerative colitis is an inflammatory bowel disease. Primary involvement is the colon. Changes in the oral cavity may occur as the part of extraintestinal manifestations of the disease.
Đuričković Aleksa   +1 more
doaj   +1 more source

Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells

open access: yesNature Communications, 2022
Cholesterol sulfate, produced by hydroxysteroid sulfotransferase 2B1 (SULT2B1), is highly abundant in the intestine. Herein, we study the functional role and underlying intestinal epithelial repair mechanisms of cholesterol sulfate in ulcerative colitis.
Dongke Xu   +14 more
semanticscholar   +1 more source

Ulcerative colitis: an update.

open access: yesClinical medicine (London), 2021
Ulcerative colitis is a relapsing and remitting disease that is increasing in incidence and prevalence. Management aims to achieve rapid resolution of symptoms, mucosal healing and improvement in a patient's quality of life.
J. Segal, J. LeBlanc, A. Hart
semanticscholar   +1 more source

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