AHR-Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg-Mediated Macrophage Efferocytosis. [PDF]
Adv Sci (Weinh)Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zhu Z +6 more
europepmc +2 more sources
Multifunctional Zinc Glycyrrhizinate-Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis. [PDF]
Adv Sci (Weinh)Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Peng M +8 more
europepmc +2 more sources
Landscape of inflammatory bowel disease in Singapore [PDF]
Intestinal Research, 2022 Inflammatory bowel disease (IBD), primarily Crohn’s disease and ulcerative colitis, had been widely recognized to affect the Western population. However, the notable rise in prevalence of IBD in Asia, including Singapore, had garnered much attention to ...
Daren Low +3 more
doaj +1 more source
Psychological stress and hypnosis in ulcerative colitis. [PDF]
, 2008 PhDPrevious studies suggest that life events and chronic stress increase the risk of relapse in inflammatory bowel disease. Furthermore, experimental stress has been shown to worsen inflammation in animal models of colitis.
Mawdsley, Joel Evan David
core +4 more sources
Diagnostics, 2021 Iron deficiency (ID) is a common manifestation of inflammatory bowel disease (IBD), arising primarily due to chronic inflammation and/or blood loss. There is no gold standard for ID diagnosis, which is often complicated by concomitant inflammation.
Eleni Leventi +4 more
doaj +1 more source
Flipside of the Coin: Iron Deficiency and Colorectal Cancer
Frontiers in Immunology, 2021 Iron deficiency, with or without anemia, is the most frequent hematological manifestation in individuals with cancer, and is especially common in patients with colorectal cancer.
Aysegül Aksan +11 more
doaj +1 more source
Current Research in Pharmacology and Drug Discovery, 2022 The number of available biological therapies have doubled over the last 10 years and the arrival of novel molecules (interleukin 23p19 inhibitors) is ongoing alongside the development of small molecules.
Pascal Juillerat +5 more
doaj +1 more source
Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis. [PDF]
, 2012 Inflammatory bowel disease (IBD) therapies are modestly successful and associated with significant side effects. Thus, the investigation of novel approaches to prevent colitis is important.
Vogel, Hans +35 more
core +2 more sources
European evidence based consensus on surgery for ulcerative colitis. [PDF]
, 2015 The goal of this consensus initiated by the European Crohn's and Colitis Organisation (ECCO) was to establish European consensus guidelines for the surgical treatment of ulcerative colitis.
Spinelli A +22 more
core +2 more sources
Long-term outcomes of infliximab in a real-world multicenter cohort of patients with acute severe ulcerative colitis [PDF]
Intestinal Research, 2021 Background/Aims Infliximab (IFX) has proven effective as rescue therapy in steroid-refractory acute severe ulcerative colitis (ASUC), however, the long-term real-world data are scarce.
Shin Ju Oh +10 more
doaj +1 more source