Results 21 to 30 of about 309,460 (288)

The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice. [PDF]

, 2013
The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis.
Bundschuh Daniela S., Siegmund Britta, Bundschuh, D.S., Endres, S., Rieder, Florian, Lehr, Hans-Anton, Lehr, H.A., Endres Stefan, Siegmund, B., Stefan Endres, Eigler, A., Eigler Andreas, Bereswill, Stefan, Daniela S. Bundschuh, Rieder, F., Bundschuh, Daniela S., Eigler, Andreas, Rieder Florian, Florian Rieder, Britta Siegmund, Lehr Hans-Anton, Siegmund, Britta, Daniela S Bundschuh, Hans-Anton Lehr, Endres, Stefan, Andreas Eigler   +25 more
core   +1 more source

Anti-NMDAR encephalitis in Crohn’s disease undergoing long-term infliximab treatment: A case report

Frontiers in Immunology, 2022
Infliximab, a chimeric monoclonal antibody against anti-tumor necrosis factor-α (TNF-α), has revolutionized the management of inflammatory bowel disease. However, a recent nested case-control study showed that anti-TNF-α therapy exposure in patients with
Shin Ju Oh, Young Nam Kwon, Chang Kyun Lee, Jin San Lee   +3 more
doaj   +1 more source

Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7) [PDF]

, 2000
Experimental colitis in mice is characterized by infiltration of activated T helper (Th) cells and macrophages into the lamina propria. Particularly, these cells expressed CD44 variant exon 7 (CD44v7)-containing isoforms.
Ursula Günthert, Margot Zöller, Günthert, U., Johansson, B., Britt Johansson, Zöller, M., Wittig, B. M., Christoph Schwärzler, Schwärzler, C., Bianca M. Wittig   +9 more
core   +1 more source

The Process of Developing a Disease Activity Index in Microscopic Colitis

, 2022
Background and Aims: Patient-reported outcome measures [PROMs] aim to measure patients' perception of how their disorder influences everyday functioning. The objective of this study was to develop a PROM to assess disease activity in microscopic colitis [
Madisch A., Munch A., Fernandez-Banares F, Lesnovska K. P., Miehlke S., Münch A, Kupcinskas J, Miehlke S, Zabana Y, Lesnovska KP, Munck LK, Munck L. K., Guagnozzi D., Fernandez-Banares F., Madisch A, Hjortswang H., Wildt S., Magro F., Tontini G. E., Latella G., Magro F, Latella G, Wildt S, Kupcinskas J., Guagnozzi D, Bonderup O, Zabana Y., Bonderup O., Tontini GE   +28 more
core   +1 more source

Noninfectious Colitides: Collagenous Colitis, Lymphocytic Colitis, Diversion Colitis, and Chemically Induced Colitis [PDF]

Clinics in Colon and Rectal Surgery, 2007
Approximately 10% of patients with chronic diarrhea carry a diagnosis of microscopic colitis. The endoscopic appearance of both collagenous colitis and lymphocytic colitis may be normal; however, biopsies confirm the diagnosis. Available treatments include antidiarrheals, bismuth salicylate, and budesonide.
openaire   +2 more sources

SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study

Annals of Medicine
Introduction Vaccination hesitancy is an important barrier to vaccination among IBD patients. The development of adverse events is the main concern reported.
Laura N. Rossier, Natalie P. Décosterd, Christoph B. Matter, Dominic A. Staudenmann, André Moser, Bernhard Egger, Frank W. Seibold   +6 more
doaj   +1 more source

Delayed Resolution of Acute Inflammation in Ulcerative Colitis Is Associated with Elevated Cytokine Release Downstream of TLR4 [PDF]

, 2010
Background: Ulcerative colitis (UC) is widely viewed as a leukocyte-mediated disorder. Although strong evidence implicates an exuberant response to microbial components in its pathogenesis, no intrinsic immune defect has been identified and the ...
Bu'Hussain Hayee, Bloom, SL, Hayee, B, Daniel J B Marks, Bloom Stuart L., Segal Anthony W., Anthony W Segal, Rahman Farooq Z., Smith Andrew M., Hayee Bu'Hussain, Rahman, FZ, Andrew M Smith, Stuart L Bloom, Marks, DJB, Marks Daniel J. B., Smith, AM, Farooq Z Rahman, Segal, AW   +17 more
core   +2 more sources

Medical trauma in young adults with inflammatory bowel disease: The role of trauma-informed care

Health Care Transitions
Medical trauma is a profound concern for those with chronic conditions like inflammatory bowel disease (IBD), especially young adults. This trauma, arising from both the disease itself and necessary medical interventions, manifests as an accumulation of ...
Amy K. Bugwadia, Sydney Reed, Mara Shapiro, Sneha Dave, Nikhil Jayswal, David Kohler, Laurie Keefer   +6 more
doaj   +1 more source

Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models [PDF]

Intestinal Research, 2020
The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease (CD) and ulcerative colitis (UC), and both ...
Emiko Mizoguchi, Daren Low, Yui Ezaki, Toshiyuki Okada   +3 more
doaj   +1 more source

Smoking in inflammatory bowel diseases: Good, bad or ugly? [PDF]

, 2007
Smoking is an important environmental factor in inflammatory bowel disease (IBD), having different effects in ulcerative colitis (UC) and Crohn’s disease (CD).
Peter Laszlo Lakatos, Lakatos, Péter László, Tamas Szamosi, Szamosi, Tamás, Laszlo Lakatos, Lakatos, László   +5 more
core   +1 more source