Results 41 to 50 of about 309,460 (288)

Fungal abundance across flare and remission in ulcerative colitis patients

Gut Pathogens
Background Ulcerative colitis (UC) is associated with gut microbiota alterations, but the role of the fungal microbiota remains underexplored. We conducted a prospective study quantifying absolute bacterial and fungal abundance in faecal samples from UC ...
Claudia Herrera-deGuise, Encarna Varela, Guillaume Sarrabayrouse, Francisca Yáñez, Luis Mayorga-Ayala, Virginia Robles-Alonso, Elena Céspedes-Martínez, Xavier Serra-Ruiz, Ernesto Lastiri, Francisco Guarner, Natalia Borruel Sainz   +10 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Providing LGBTQ+ affirming care to young adults with inflammatory bowel diseases

Health Care Transitions
Creating an affirming care environment for young adults with IBD in the LGBTQ+ community is an essential part of inflammatory bowel disease (IBD) care.
Cade Johnson, Sneha Dave, Sydney Reed, Victor Chedid, Lucy Laube, Laura Targownik   +5 more
doaj   +1 more source

Sodium chloride-enriched Diet Enhanced Inflammatory Cytokine Production and Exacerbated Experimental Colitis in Mice

, 2017
BACKGROUND AND AIM: Environmental factors are supposed to play a decisive role in the pathogenesis of inflammatory bowel diseases [IBDs]. Increased dietary salt intake has been linked with the development of autoimmune diseases, but the impact of a salt ...
Di Fusco, D, Marafini, I, Di Fusco, Davide, Monteleone, Ivan, Dinallo, V, Troncone, E, DINALLO, VINCENZO, Zorzi, F, Monteleone, Giovanni, Troncone, Edoardo, Laudisi, F, Monteleone, I, Monteleone, G, Laudisi, Federica, MARAFINI, IRENE, Zorzi, Francesca   +15 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sexual and reproductive health considerations in the care of young adults with inflammatory bowel disease: A multidisciplinary conversation

Health Care Transitions
The effects of inflammatory bowel disease (IBD) and the medications used to treat it on sexual and reproductive health can be significant, impacting the quality of life of patients across gender identities.
Sydney Reed, Amy K. Bugwadia, Sneha Dave, Hannah E. Wilson, Prathikka Ramesh, Hilary K. Michel   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Clinical trials and young adults with inflammatory bowel disease

Health Care Transitions
Young adults (approximately 18–35 years) with inflammatory bowel disease (IBD) represent a distinct demographic with unique developmental and physiological characteristics, yet they are underrepresented in clinical trials.
Sneha Dave, Sydney Reed, Mara Shapiro, Yeabsira Taye, Isabela Hernandez, Navin Kariyawasam, Ildiko Mehes, Manasi Agrawal, Miguel Regueiro, Adam Faye, Jeremy Adler   +10 more
doaj   +1 more source

Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect

Microorganisms, 2021
Colonization by the benign tapeworm, Hymenolepis diminuta, has been associated with a reduction in intestinal inflammation and changes in bacterial microbiota. However, the role of microbiota in the tapeworm anti-inflammatory effect is not yet clear, and
Milan Jirků, Zuzana Lhotská, Lucia Frgelecová, Oldřiška Kadlecová, Klára Judita Petrželková, Evan Morien, Kateřina Jirků-Pomajbíková   +6 more
doaj   +1 more source