Results 211 to 220 of about 215,870 (306)

Characteristics, properties and limitations of per‐ or polyfluoroalkyl substances (PFASs) and fluoropolymers

open access: yesPolymer International, EarlyView.
An overview and categorization of man‐made per‐ or polyfluoroalkyl substances (PFASs) including low‐molar‐mass and high‐molar‐mass fluorochemicals, and their international regulations is presented. Though certain PFASs are toxic, bioaccumulative and cross the human cellular membranes, others, such as fluoropolymers, are safe, reliable and involved in ...
Bruno Améduri
wiley   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani   +5 more
wiley   +1 more source

Rapidly Progressive Cutaneous Nodules in an Elderly Woman

open access: yes
JEADV Clinical Practice, EarlyView.
Valeria Olvera‐Rodriguez   +5 more
wiley   +1 more source

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

open access: yesPhytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou   +9 more
wiley   +1 more source

General and central obesities were associated with increased risk of inflammatory bowel disease: A large‐scale prospective cohort study

open access: yesVIEW, EarlyView.
Prior evidence suggested inconsistent findings in terms of the relationship between obesity and inflammatory bowel disease (IBD) occurrence. We demonstrated that both general and central obesities were associated with an increased risk of developing IBD, ulcerative colitis, and Crohn's disease in a large‐scale prospective cohort.
Qian Zhang   +5 more
wiley   +1 more source

Redefining “Comorbidity” in Dermatology: Beyond Terminology, Lessons From Other Specialties

open access: yes
JEADV Clinical Practice, EarlyView.
Patricia Garbayo‐Salmons   +1 more
wiley   +1 more source

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