Results 231 to 240 of about 215,870 (306)

Frailty Is Associated With All‐Cause and Acute Hospitalisations During 18 Months Follow‐Up in Older Patients With Inflammatory Bowel Disease

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
The results of a geriatric assessment in older patients with IBD were associated with adverse health outcomes. Frailty, reflected by severe deficits in geriatric assessment, was independently associated with all‐cause and acute hospitalisations in older patients with IBD. ABSTRACT Background Guidelines recommend considering frailty in the management of
Anne B. Fons   +10 more
wiley   +1 more source

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez   +6 more
wiley   +1 more source

Emerging role of Janus kinase inhibitors in ulcerative colitis management. [PDF]

open access: yesWorld J Gastrointest Pharmacol Ther
Ahsan MU   +5 more
europepmc   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud   +9 more
wiley   +1 more source

Wuji Wan ameliorates ulcerative colitis by restoring impaired membrane transport. [PDF]

open access: yesFront Pharmacol
Zhang J   +11 more
europepmc   +1 more source

Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers

open access: yesCancer Science, EarlyView.
Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu   +5 more
wiley   +1 more source

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