Results 41 to 50 of about 1,869,744 (283)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

ULTIMATE STRENGTH ANALYSIS OF SHIP STRUCTURES

open access: yesINTERNATIONAL JOURNAL OF DESIGN AND MANUFACTURING TECHNOLOGY, 2014
Subjective and objective uncertainties are imposed on ship structures due to the random nature of the loading environment, inadequate knowledge of physical phenomena associated with loads or deviations in material properties which make reliable predictions of structural response a difficult task.
P. G. SUNIL KUMAR, S. SATHISH KUMAR
openaire   +1 more source

International competitiveness power and human development of countries [PDF]

open access: yes, 2007
Human development should be the ultimate objective of human activity and its aim should be healthier, longer, and fuller lives. It is expected that if the competitiveness of a country is suitably managed, human welfare will be enhanced as a consequence.
Aktas, Emel   +9 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Correlations to Predict Elemental Compositions and Heating Value of Torrefied Biomass

open access: yesEnergies, 2018
Measurements reported in the literature on ultimate analysis of various types of torrefied woody biomass, comprising 152 data points, have been compiled and empirical correlations are developed to predict the carbon content, hydrogen content, and heating
Mahmudul Hasan   +2 more
doaj   +1 more source

Experimental Analysis and Optimization to Maximize Ultimate Tensile Strength and Ultimate Elongation of Friction Stir Welded AA6082 Aluminum Alloy

open access: yesMetals, 2020
Friction stir welding (FSW) is a well-established welding technique, which allows joining abutting surfaces by generating heating through a rotating and translating tool specifically shaped.
Michela Simoncini   +3 more
doaj   +1 more source

Where the Twain Shall Meet: Standing and Remedy in Alaska Center for the Environment v. Browner [PDF]

open access: yes, 1996
In 1994, the Ninth Circuit affirmed standing for citizens to sue to compel the EPA Administrator to undertake a statewide TMDL program. Although the citizens had standing for only some of the water-quality-limited waters in Alaska, the court held that ...
Bruch, Carl E.
core   +1 more source

Increased variability of microbial communities in restored salt marshes nearly 30 years after tidal flow restoration [PDF]

open access: yes, 2012
We analyzed microbial diversity and community composition from four salt marsh sites that were impounded for 40–50 years and subsequently restored and four unimpounded sites in southeastern Connecticut over one growing season.
Bernhard, Anne E   +2 more
core   +3 more sources

Advancing liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry toward ultra-high-throughput analysis [PDF]

open access: yes, 2020
Label-free high-throughput screening using mass spectrometry has the potential to provide rapid large-scale sample analysis at a speed of more than one sample per second.
Brown, Jeffery   +5 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

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