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The Ultra High Risk Approach to Define Psychosis Risk
Current Pharmaceutical Design, 2012Although prodromal symptoms of psychosis have long been recognized, the clinical management of psychotic disorders conventionally begins at the first episode of frank psychosis, and, until recently, the period immediately preceding the first episode received relatively little attention.
Yung, Alison R. +2 more
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Prolonged Isotretinoin in Ultra High-Risk Neuroblastoma
Journal of Pediatric Hematology/Oncology, 2017Patients with high-risk neuroblastoma remain a therapeutic challenge with significant numbers of patients failing to respond sufficiently to initial therapy. These patients with poor response to induction are considered as ultra high-risk and are in need of novel treatment strategies.
Thomas, Cash +3 more
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The challenge of defining “ultra‐high‐risk” neuroblastoma
Pediatric Blood & Cancer, 2018AbstractGiven the biological and clinical heterogeneity of neuroblastoma, risk stratification is vital to determining appropriate treatment. Historically, most patients with high‐risk neuroblastoma (HR‐NBL) have been treated uniformly without further stratification.
Daniel A. Morgenstern +11 more
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Schizophrenia Research, 2023
People who are at ultra-high risk (UHR) for psychosis receive clinical care with the aim to prevent first-episode psychosis (FEP), regardless of the risk of conversion to psychosis. An economic model from the Canadian health system perspective was developed to evaluate the cost-effectiveness of treating all with UHR compared to risk stratification over
Ologundudu, Olajumoke M. +5 more
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People who are at ultra-high risk (UHR) for psychosis receive clinical care with the aim to prevent first-episode psychosis (FEP), regardless of the risk of conversion to psychosis. An economic model from the Canadian health system perspective was developed to evaluate the cost-effectiveness of treating all with UHR compared to risk stratification over
Ologundudu, Olajumoke M. +5 more
openaire +3 more sources
Hematology, 2010
Abstract Ultra high-risk myeloma can be defined as myeloma leading to death within 24 months. Despite tremendous improvements in the past decade (especially because of the availability of novel drugs such as thalidomide, bortezomib, and lenalidomide), these patients still represent 15% to 20% of the patients.
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Abstract Ultra high-risk myeloma can be defined as myeloma leading to death within 24 months. Despite tremendous improvements in the past decade (especially because of the availability of novel drugs such as thalidomide, bortezomib, and lenalidomide), these patients still represent 15% to 20% of the patients.
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Ultra High-risk Gestational Trophoblastic Neoplasia
Hematology/Oncology Clinics of North AmericaUltra high-risk gestational trophoblastic neoplasia (GTN) refers to patients with World Health Organization prognostic risk scores of at least 13. The mortality risk for these patients averages 30%. Ultra high-risk GTN more frequently presents with higher tumor volume, liver and/or brain metastases, and very high human chorionic gonadotropin levels ...
Kevin M, Elias +2 more
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Understanding and Managing Ultra High-Risk Chronic Lymphocytic Leukemia
Hematology, 2010AbstractModern treatment approaches such as chemoimmunotherapy (e.g., fludarabine/cyclophosphamide/rituximab or FCR) are highly effective in the majority of chronic lymphocytic leukemia (CLL) patients. However, there remains a small but challenging subgroup of patients who show ultra high-risk genetics (17p deletion, TP53 mutation) and/or poor response
Stephan, Stilgenbauer, Thorsten, Zenz
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Ultra-high-risk paradigm: lessons learnt and new directions
Evidence Based Mental Health, 2018Within the embryonic early psychosis field in the early 1990s, the conceptualisation and definition of an at-risk or ultra-high-risk (UHR) mental state for psychosis was a breakthrough which transformed the clinical and research landscape in psychiatry.
Patrick D, McGorry, Cristina, Mei
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Ultra-high-risk pregnancies in women after renal transplantation
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2014This study evaluates pregnancy outcomes in renal transplant recipients who have additional obstetrical, surgical, or urological risk factors.Data from our transplantation and obstetrical databases were retrospectively analyzed to identify all women of reproductive age who had undergone renal transplantation between 1999 and 2013 at our tertiary ...
Alex Farr +5 more
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Can Clinicians Predict Psychosis in an Ultra High Risk Group?
Australian & New Zealand Journal of Psychiatry, 2010Aims: Criteria for identifying people likely to develop a first psychotic episode are now used in many clinical services worldwide. In recent years within these services, there has been an increase in the practice of prescribing antipsychotic medication with the aim of reducing symptoms and preventing onset of full-blown disorder.
Nelson, Barnaby, Yung, Alison R.
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